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1
Analysis of risk factors for recurrence after laparoscopic myomectomy: A retrospective study.腹腔镜子宫肌瘤切除术后复发危险因素分析:一项回顾性研究。
Medicine (Baltimore). 2025 Mar 14;104(11):e41697. doi: 10.1097/MD.0000000000041697.
2
Minimally invasive surgical techniques versus open myomectomy for uterine fibroids.子宫肌瘤的微创手术技术与开腹子宫肌瘤切除术对比
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3
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Cochrane Database Syst Rev. 2001(2):CD000547. doi: 10.1002/14651858.CD000547.
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Impact of definitive uterine artery occlusion on ovarian reserve markers in laparoscopic myomectomy: a randomized controlled trial with 2-year follow-up.根治性子宫动脉闭塞对腹腔镜子宫肌瘤剔除术中卵巢储备指标的影响:一项为期2年随访的随机对照试验
Hum Reprod. 2025 Jul 1;40(7):1305-1314. doi: 10.1093/humrep/deaf070.
6
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7
Pre-operative GnRH analogue therapy before hysterectomy or myomectomy for uterine fibroids.子宫肌瘤患者在子宫切除术或肌瘤切除术之前进行术前促性腺激素释放激素类似物治疗。
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8
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Preoperative medical therapy before surgery for uterine fibroids.子宫肌瘤手术前的术前医学治疗。
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本文引用的文献

1
Genetic Mechanisms Driving Uterine Leiomyoma Pathobiology, Epidemiology, and Treatment.遗传机制驱动子宫肌瘤的病理生物学、流行病学和治疗。
Genes (Basel). 2024 Apr 27;15(5):558. doi: 10.3390/genes15050558.
2
Combined oral contraceptive utilization and uterine fibroid incidence: A prospective study in a cohort of African-American women.口服避孕药的使用与子宫肌瘤发病率:一项在非裔美国女性队列中的前瞻性研究。
PLoS One. 2024 May 23;19(5):e0303823. doi: 10.1371/journal.pone.0303823. eCollection 2024.
3
The great debate: Surgical outcomes of laparoscopic versus laparotomic myomectomy. A meta-analysis to critically evaluate current evidence and look over the horizon.腹腔镜与开腹子宫肌瘤剔除术的疗效比较:一场大辩论。一项旨在批判性评估现有证据并展望未来的荟萃分析。
Eur J Obstet Gynecol Reprod Biol. 2024 Jun;297:50-58. doi: 10.1016/j.ejogrb.2024.03.045. Epub 2024 Apr 1.
4
Causal relationship between female reproductive factors, sex hormones and uterine leiomyoma: a Mendelian randomization study.女性生殖因素、性激素与子宫肌瘤之间的因果关系:一项孟德尔随机化研究
Reprod Biomed Online. 2024 Feb;48(2):103584. doi: 10.1016/j.rbmo.2023.103584. Epub 2023 Oct 2.
5
Obesity Contributes to Transformation of Myometrial Stem-Cell Niche to Leiomyoma via Inducing Oxidative Stress, DNA Damage, Proliferation, and Extracellular Matrix Deposition.肥胖通过诱导氧化应激、DNA 损伤、增殖和细胞外基质沉积,导致子宫平滑肌瘤的肌源性干细跑巢的转化。
Genes (Basel). 2023 Aug 15;14(8):1625. doi: 10.3390/genes14081625.
6
Genetic liability to multiple factors and uterine leiomyoma risk: a Mendelian randomization study.遗传因素与子宫肌瘤风险的多因素遗传易感性:一项孟德尔随机化研究。
Front Endocrinol (Lausanne). 2023 Jul 27;14:1133260. doi: 10.3389/fendo.2023.1133260. eCollection 2023.
7
Analysis of risk factors for postoperative bleeding and recurrence after laparoscopic myomectomy in patients with uterine fibroids: a retrospective cohort study.子宫肌瘤患者腹腔镜子宫肌瘤切除术后出血和复发的危险因素分析:一项回顾性队列研究
Gland Surg. 2023 Apr 28;12(4):474-486. doi: 10.21037/gs-23-92.
8
Adipocyte and Adipokines Promote a Uterine Leiomyoma Friendly Microenvironment.脂肪细胞和脂肪细胞因子促进子宫肌瘤的有利微环境。
Nutrients. 2023 Jan 31;15(3):715. doi: 10.3390/nu15030715.
9
The Effect of Estrogen-Related Genetic Variants on the Development of Uterine Leiomyoma: Meta-analysis.雌激素相关遗传变异对子宫肌瘤发生发展的影响:Meta 分析。
Reprod Sci. 2022 Jun;29(6):1921-1929. doi: 10.1007/s43032-022-00911-4. Epub 2022 Apr 12.
10
Molecular and Cellular Insights into the Development of Uterine Fibroids.子宫纤维瘤发病机制的分子和细胞研究进展
Int J Mol Sci. 2021 Aug 6;22(16):8483. doi: 10.3390/ijms22168483.

腹腔镜子宫肌瘤切除术后复发危险因素分析:一项回顾性研究。

Analysis of risk factors for recurrence after laparoscopic myomectomy: A retrospective study.

作者信息

Meng Tingzhu, Cheng Shiyu, Li Xin, Gao Han, Li Yanli, Du Mei, Shi Jie

机构信息

Department of Gynecology, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Medical College, Wuhan University of Science and Technology, Wuhan, China.

出版信息

Medicine (Baltimore). 2025 Mar 14;104(11):e41697. doi: 10.1097/MD.0000000000041697.

DOI:10.1097/MD.0000000000041697
PMID:40101032
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11922446/
Abstract

At present, there is unclear on the risk factors of recurrence after myomectomy. In this study, we hope to provide reference for the choice of treatment for patients with uterine fibroids and provide basis for the subsequent prediction of recurrence. From October 2020 to October 2022, we enrolled 240 patients with uterine fibroids in Hubei Maternal and Child Health Hospital. According to the inclusion criteria, the collected clinical data of these patients were analyzed and divided into 2 groups according to whether there was recurrence 6 months after surgery(a recurrence group [52 cases] and a non-recurrence group [78 cases]). We compared and analyzed the relevant factors. Univariate analysis showed that there was no significant relationship between fibroid diameter, postoperative pregnancy, contraceptive method, hyperlipidemia, diabetes, endometriosis and postoperative recurrence (P > .05). While, age, number of pregnancies, number of fibroids, type of fibroids, body mass index, endometrial hyperplasia or endometrial polyp were significantly correlated with postoperative recurrence (P < .05). Multivariate Logistic regression analysis demonstrated that body mass index > 24, number of pregnancies > 2, multiple myoma, intermyoma and endometrial hyperplasia were independent risk factors for postoperative myoma recurrence (P < .05). Body mass index > 24, number of pregnancies > 2, multiple fibroids, intermyowall fibroids, and endometrial hyperplasia are all independent risk factors for recurrence after laparoscopic myomectomy in patients with uterine fibroids. Patients with these independent risk factors should be closely reviewed. If they have multiple independent risk factors and have no fertility requirements are present, hysterectomy may be recommended.

摘要

目前,子宫肌瘤剔除术后复发的危险因素尚不清楚。在本研究中,我们希望为子宫肌瘤患者的治疗选择提供参考,并为后续复发预测提供依据。2020年10月至2022年10月,我们纳入了湖北省妇幼保健院的240例子宫肌瘤患者。根据纳入标准,对这些患者收集的临床资料进行分析,并根据术后6个月是否复发分为2组(复发组[52例]和未复发组[78例])。我们对相关因素进行了比较和分析。单因素分析显示,肌瘤直径、术后妊娠、避孕方法、高脂血症、糖尿病、子宫内膜异位症与术后复发之间无显著关系(P>0.05)。而年龄、妊娠次数、肌瘤数量、肌瘤类型、体重指数、子宫内膜增生或子宫内膜息肉与术后复发显著相关(P<0.05)。多因素Logistic回归分析表明,体重指数>24、妊娠次数>2、多发性肌瘤、肌壁间肌瘤和子宫内膜增生是术后肌瘤复发的独立危险因素(P<0.05)。体重指数>24、妊娠次数>2、多发性肌瘤、肌壁间肌瘤和子宫内膜增生均是子宫肌瘤患者腹腔镜肌瘤剔除术后复发的独立危险因素。具有这些独立危险因素的患者应密切复查。如果他们有多个独立危险因素且无生育要求,可建议行子宫切除术。