Ning Gang, Li Bo-Nan, Wu Hui, Shi Ruo-Bing, Peng A-Jian, Wang Hao-Yu, Zhou Xing
The First Clinical College of Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, China.
Department of Andrology, The First Hospital of Hunan University of Chinese Medicine, Changsha 410007, China.
Asian J Androl. 2025 Sep 1;27(5):564-573. doi: 10.4103/aja20258. Epub 2025 Mar 18.
The circadian clock is an important internal time regulatory system for a range of physiological and behavioral rhythms within living organisms. Testosterone, as one of the most critical sex hormones, is essential for the development of the reproductive system, maintenance of reproductive function, and the overall health of males. The secretion of testosterone in mammals is characterized by distinct circadian rhythms and is closely associated with the regulation of circadian clock genes. Here we review the central and peripheral regulatory mechanisms underlying the influence of circadian clock genes upon testosterone synthesis. We also examined the specific effects of these genes on the occurrence, development, and treatment of common male diseases, including late-onset hypogonadism, erectile dysfunction, male infertility, and prostate cancer.
生物钟是生物体内一系列生理和行为节律的重要内部时间调节系统。睾酮作为最关键的性激素之一，对雄性生殖系统的发育、生殖功能的维持以及整体健康至关重要。哺乳动物体内睾酮的分泌具有明显的昼夜节律特征，并且与生物钟基因的调控密切相关。在此，我们综述生物钟基因对睾酮合成影响的中枢和外周调节机制。我们还研究了这些基因对常见男性疾病（包括迟发性性腺功能减退、勃起功能障碍、男性不育症和前列腺癌）的发生、发展及治疗的具体影响。
