丹酚酸B（SalB）通过在体内和体外调节Trem2/Dap12信号通路改善高脂饮食（HFD）诱导的小鼠认知障碍。
Salvianolic acid B (SalB) improves high-fat diet (HFD)-caused cognitive impairment in mice by modulating the Trem2/Dap12 pathway in vivo and in vitro.
作者信息
Li Hong-Dan, Zheng Jia-Yi, Tan Kai-Wen, Su Jin-Xun, Chen Wei, Pang Rui-Kang, Wu Guang-Liang, Qiu Yu-Hui, Li Xiao-Xiao, Cai Ye-Feng, Zhang Shi-Jie
机构信息
Department of Neurology, Nanning Hospital of Traditional Chinese Medicine, Nanning 530000, China; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, China; Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China; Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou 510000, China.
State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, China; Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China; Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China; Guangdong Provincial Key Laboratory of Research on Emergency in TCM, Guangzhou 510000, China.
出版信息
Int Immunopharmacol. 2025 Apr 24;153:114461. doi: 10.1016/j.intimp.2025.114461. Epub 2025 Mar 17.
Salvianolic acid B (SalB), which extracted from Salvia miltiorrhiza Bunge (Labiatae), is a traditional Chinese medicine. SalB is widely used in nervous system diseases. This study evaluated the protective effect of SalB on high-fat diet (HFD)-induced cognitive impairment and its mechanisms in vivo and in vitro. The behavior tests demonstrated that SalB alleviated motor skills and learning capacity in HFD mice. Animal experiments have confirmed that SalB reduced the mRNA expression of inflammatory markers and the Trem2/Dap12 pathway in HIP. Furthermore, SalB inhibited the microglia Trem2/Dap12 pathway in HIP. In vivo, palmitic acid (PA) was used to intervene in BV2 cells to construct an inflammatory. SalB reduced the mRNA expression of inflammatory markers and inhibited the Trem2/Dap12 pathway in BV2 cells. In conclusion, SalB treatment may serve as a possible therapy for cognitive impairment induced by HFD.
丹酚酸B（SalB）是从丹参（唇形科）中提取的一种传统中药。SalB广泛应用于神经系统疾病。本研究评估了SalB对高脂饮食（HFD）诱导的认知障碍的保护作用及其体内和体外机制。行为测试表明，SalB改善了HFD小鼠的运动技能和学习能力。动物实验证实，SalB降低了海马中炎症标志物的mRNA表达以及Trem2/Dap12信号通路。此外，SalB抑制了海马中微胶质细胞的Trem2/Dap12信号通路。在体内，使用棕榈酸（PA）干预BV2细胞以构建炎症模型。SalB降低了BV2细胞中炎症标志物的mRNA表达并抑制了Trem2/Dap12信号通路。总之，SalB治疗可能是治疗HFD诱导的认知障碍的一种可行疗法。
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