Suh Jee Hyun, Heo Seok-Jae, Kim Yong Wook, Lee Sang Chul, Yoon Seo Yeon
Department of Rehabilitation Medicine, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea.
Department of Biostatistics and Computing, Yonsei University Graduate School, Seoul, Republic of Korea.
Sci Rep. 2025 Mar 18;15(1):9251. doi: 10.1038/s41598-025-92624-2.
Despite many previous studies on the association between metabolic syndrome and Parkinson disease (PD), only few studies have investigated the association between waist circumference (WC) and PD. The aim of this study is to investigate the association between WC and all-cause mortality in patients with PD. Among the whole nationwide population data from Korea National Health Insurance Service, newly diagnosed PD (ICD-10 code G20 and rare intractable disease registration code V124), between 2008 and 2017, were selected. All-cause mortality was the primary outcome. Anthropometric data, including WC and body mass index (BMI) were obtained from health screening data. The Cox proportional hazards model was used to assess mortality risk according to WC. Among the 22,118 patients with PD, 9,179 (41.50%) died during the 10-year follow-up period. WCs < 70 cm among males and < 65 cm among females were significantly associated with increased mortality in patients with PD (HR = 1.19, 95% CI, 1.05-1.34). After adjusting for BMI, WC of ≥ 90 cm in males or ≥ 85 cm in females, which are the criteria for central obesity, increased mortality risk significantly (M 90-100, F 85-95: HR = 1.13, 95% CI, 1.05-1.22; M ≥ 100, F ≥ 95: HR = 1.50, 95% CI, 1.33-1.68). The association between WC and PD mortality revealed a J-shaped pattern among males and a U-shaped pattern among females. Central obesity is a significant risk factor for mortality in patients with PD after adjusting for BMI. Our results suggest that management of WC is crucial for PD patients and that BMI should be considered in the WC management plan for mortality in PD.
尽管之前有许多关于代谢综合征与帕金森病（PD）之间关联的研究，但仅有少数研究调查了腰围（WC）与PD之间的关联。本研究的目的是调查PD患者中WC与全因死亡率之间的关联。在韩国国民健康保险服务的全国总体人群数据中，选取了2008年至2017年间新诊断的PD（国际疾病分类第十版代码G20和罕见难治性疾病登记代码V124）。全因死亡率是主要结局。包括WC和体重指数（BMI）在内的人体测量数据来自健康筛查数据。采用Cox比例风险模型根据WC评估死亡风险。在22118例PD患者中，9179例（41.50%）在10年随访期内死亡。男性WC<70 cm且女性WC<65 cm与PD患者死亡率增加显著相关（风险比[HR]=1.19，95%置信区间[CI]，1.05 - 1.34）。在调整BMI后，男性WC≥90 cm或女性WC≥85 cm（即中心性肥胖的标准）显著增加死亡风险（男性90 - 100，女性85 - 95：HR = 1.13，95% CI，1.05 - 1.22；男性≥100，女性≥95：HR = 1.50，95% CI，1.33 - 1.68）。WC与PD死亡率之间的关联在男性中呈J形模式，在女性中呈U形模式。在调整BMI后，中心性肥胖是PD患者死亡的显著危险因素。我们的结果表明，WC管理对PD患者至关重要，并且在PD死亡率的WC管理计划中应考虑BMI。
