Kang Sung Hoon, Moon Seok-Joo, Kang Minwoong, Chung Su Jin, Cho Geum Joon, Koh Seong-Beom
Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
Smart Healthcare Center, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
Front Aging Neurosci. 2023 Feb 14;15:1094778. doi: 10.3389/fnagi.2023.1094778. eCollection 2023.
We aimed to investigate the incidence of Parkinson's disease (PD) by age and year for each sex as well as the modifiable risk factors for PD. Using data from the Korean National Health Insurance Service, 938,635 PD and dementia-free participants aged ≥40 years who underwent general health examinations were followed to December 2019.
We analyzed the PD incidence rates according to age, year and sex. To investigate the modifiable risk factors for PD, we used the Cox regression model. Additionally, we calculated the population-attributable fraction to measure the impact of the risk factors on PD.
During follow-up, 9,924 of the 938,635 (1.1%) participants developed PD. The incidence of PD increased continuously from 2007 to 2018, reaching 1.34 per 1,000 person-years in 2018. The incidence of PD also increases with age, up to 80 y. Presence of hypertension (SHR = 1.09, 95% CI 1.05 to 1.14), diabetes (SHR = 1.24, 95% CI 1.17 to 1.31), dyslipidemia (SHR = 1.12, 95% CI 1.07 to 1.18), ischemic stroke (SHR = 1.26, 95% CI 1.17 to 1.36), hemorrhagic stroke (SHR = 1.26, 95% CI 1.08 to 1.47), ischemic heart disease (SHR = 1.09, 95% CI 1.02 to 1.17), depression (SHR = 1.61, 95% CI 1.53 to 1.69), osteoporosis (SHR = 1.24, 95% CI 1.18 to 1.30), and obesity (SHR = 1.06, 95% CI 1.01 to 1.10) were independently associated with a higher risk for PD.
Our results highlight the effect of modifiable risk factors for PD in the Korean population, which will help establish health care policies to prevent the development of PD.
我们旨在按年龄和年份分别调查帕金森病（PD）在男性和女性中的发病率以及PD的可改变风险因素。利用韩国国民健康保险服务的数据，对938,635名年龄≥40岁且未患痴呆症并接受了全面健康检查的参与者进行随访至2019年12月。
我们分析了按年龄、年份和性别划分的PD发病率。为了研究PD的可改变风险因素，我们使用了Cox回归模型。此外，我们计算了人群归因分数以衡量风险因素对PD的影响。
在随访期间，938,635名参与者中有9,924人（1.1%）患上了PD。PD的发病率从2007年到2018年持续上升，在2018年达到每1000人年1.34例。PD的发病率也随年龄增长而上升，直至80岁。患有高血压（风险比[SHR]=1.09，95%置信区间[CI]为1.05至1.14）、糖尿病（SHR = 1.24，95% CI为1.17至1.31）、血脂异常（SHR = 1.12，95% CI为1.07至1.18）、缺血性中风（SHR = 1.26，95% CI为1.17至1.36）、出血性中风（SHR = 1.26，95% CI为1.08至1.47）、缺血性心脏病（SHR = 1.09，95% CI为1.02至1.17）、抑郁症（SHR = 1.61，95% CI为1.53至1.69）、骨质疏松症（SHR = 1.24，95% CI为1.18至1.30）和肥胖症（SHR = 1.06，95% CI为1.01至1.10）均与患PD的较高风险独立相关。
我们的结果突出了可改变风险因素对韩国人群中PD的影响，这将有助于制定预防PD发生的医疗保健政策。
