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Targeting anti-androgen therapy resistance through epigenetic rewiring.

作者信息

Dunmore Kate E, Rickman David S

机构信息

Weill Cornell Graduate School of Medical Sciences, New York, NY, USA.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.

出版信息

Nat Cancer. 2025 Apr;6(4):564-566. doi: 10.1038/s43018-025-00906-5.

DOI:10.1038/s43018-025-00906-5
PMID:40102672
Abstract
摘要

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本文引用的文献

1
Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets.染色质特征可对去势抵抗性前列腺癌进行分类,提示治疗靶点。
Science. 2022 May 27;376(6596):eabe1505. doi: 10.1126/science.abe1505.
2
ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer.ASCL1 通过重塑前列腺癌中的染色质景观激活神经干细胞样谱系编程。
Nat Commun. 2022 Apr 27;13(1):2282. doi: 10.1038/s41467-022-29963-5.
3
Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer.
针对增强子成瘾性前列腺癌的 SWI/SNF ATPases。
Nature. 2022 Jan;601(7893):434-439. doi: 10.1038/s41586-021-04246-z. Epub 2021 Dec 22.
4
Suppression of poised oncogenes by ZMYND8 promotes chemo-sensitization.ZMYND8 抑制稳定的癌基因促进化疗敏感性。
Cell Death Dis. 2020 Dec 15;11(12):1073. doi: 10.1038/s41419-020-03129-x.
5
Whole-Genome and Transcriptional Analysis of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer Demonstrates Intraclass Heterogeneity.治疗后小细胞神经内分泌前列腺癌的全基因组和转录组分析显示出类内异质性。
Mol Cancer Res. 2019 Jun;17(6):1235-1240. doi: 10.1158/1541-7786.MCR-18-1101. Epub 2019 Mar 27.
6
Positive Regulation of Transcription by Human ZMYND8 through Its Association with P-TEFb Complex.人 ZMYND8 通过与 P-TEFb 复合物的结合正向调控转录。
Cell Rep. 2018 Aug 21;24(8):2141-2154.e6. doi: 10.1016/j.celrep.2018.07.064.
7
Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study.治疗后出现的小细胞神经内分泌前列腺癌的临床和基因组特征:一项多机构前瞻性研究。
J Clin Oncol. 2018 Aug 20;36(24):2492-2503. doi: 10.1200/JCO.2017.77.6880. Epub 2018 Jul 9.
8
ZMYND8 acetylation mediates HIF-dependent breast cancer progression and metastasis.ZMYND8 乙酰化介导 HIF 依赖性乳腺癌的进展和转移。
J Clin Invest. 2018 May 1;128(5):1937-1955. doi: 10.1172/JCI95089. Epub 2018 Apr 9.
9
Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling.雄激素受体信号通路非依赖性前列腺癌通过成纤维细胞生长因子信号得以维持。
Cancer Cell. 2017 Oct 9;32(4):474-489.e6. doi: 10.1016/j.ccell.2017.09.003.
10
SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer.SOX2促进TP53和RB1缺陷型前列腺癌中的谱系可塑性和抗雄激素耐药性。
Science. 2017 Jan 6;355(6320):84-88. doi: 10.1126/science.aah4307.