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重复经颅磁刺激对血管性认知障碍大鼠学习记忆认知功能的影响及其神经诱导机制

Effects of repetitive transcranial magnetic stimulation on learning and memory cognitive function in rats with vascular cognitive impairment and its neural induction mechanism.

作者信息

Wang Jiati, Gao Huan

机构信息

Department of Neurology, Yan'an University Xianyang Hospital, Xianyang, 712000, Shaanxi, China.

出版信息

BMC Neurosci. 2025 Mar 18;26(1):24. doi: 10.1186/s12868-025-00933-z.

DOI:10.1186/s12868-025-00933-z
PMID:40102718
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11916909/
Abstract

BACKGROUND

The treatment of vascular cognitive impairment (VCI) is challenging, and its neurological mechanisms are not yet fully understood. Repetitive transcranial magnetic stimulation (rTMS) offers a new non-invasive treatment approach.

METHODS

One hundred male SD rats were grouped: intervention group (IG), model group (MG), sham group (SG), and control group (CG), to prepare the rat model of VCI. The Morris water maze (MWM) test was conducted, and oxidative stress (OS) markers, neurotrophic factors, apoptosis factors, and the amplitude of postsynaptic potential (PSP) in the hippocampus of rats were measured.

RESULTS

Post-intervention, IG's escape latency was lower than MG but higher than SG and CG. IG's hippocampal malondialdehyde (MDA) content, Bax, and Caspase-3 (Cas-3) were lower than MG but higher than SG and CG, while the tendency was opposite for Bcl-2 expression and the content of glutathione (GSH) and superoxide dismutase (SOD). IG's brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), and N-methyl-D-aspartate receptor 1 (NMDAR1) in the hippocampus were higher than MG but lower than SG and CG; The changes in the amplitude of PSP in the hippocampal region of IG at 10, 30, and 60 min were all higher than those in MG but lower than those in SG and CG (P < 0.05).

CONCLUSION

Low-frequency rTMS visibly improved the learning and memory abilities of VCI rats and reduced OS levels.

摘要

背景

血管性认知障碍（VCI）的治疗具有挑战性，其神经机制尚未完全明确。重复经颅磁刺激（rTMS）提供了一种新的非侵入性治疗方法。

方法

将100只雄性SD大鼠分组：干预组（IG）、模型组（MG）、假手术组（SG）和对照组（CG），制备VCI大鼠模型。进行莫里斯水迷宫（MWM）试验，并检测大鼠海马中的氧化应激（OS）标志物、神经营养因子、凋亡因子以及突触后电位（PSP）的幅度。

结果

干预后，IG的逃避潜伏期低于MG，但高于SG和CG。IG的海马丙二醛（MDA）含量、Bax和半胱天冬酶-3（Cas-3）低于MG，但高于SG和CG，而Bcl-2表达以及谷胱甘肽（GSH）和超氧化物歧化酶（SOD）含量的趋势则相反。IG海马中的脑源性神经营养因子（BDNF）、胶质细胞源性神经营养因子（GDNF）和N-甲基-D-天冬氨酸受体1（NMDAR1）高于MG，但低于SG和CG；IG在10、30和60分钟时海马区PSP幅度的变化均高于MG，但低于SG和CG（P<0.05）。

结论

低频rTMS明显改善了VCI大鼠的学习和记忆能力，并降低了OS水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be7/11916909/e2ba0798c61a/12868_2025_933_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be7/11916909/d9c2da15206c/12868_2025_933_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be7/11916909/6128b2f1cc32/12868_2025_933_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be7/11916909/e2ba0798c61a/12868_2025_933_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be7/11916909/d9c2da15206c/12868_2025_933_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be7/11916909/2cc58ff31140/12868_2025_933_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be7/11916909/9e32e5a3adc5/12868_2025_933_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be7/11916909/6d593688dbdd/12868_2025_933_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be7/11916909/6128b2f1cc32/12868_2025_933_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be7/11916909/e2ba0798c61a/12868_2025_933_Fig6_HTML.jpg

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