Kara Betul, Gordon Marcia N, Gifani Mahsa, Dorrance Anne M, Counts Scott E
Department of Translational Neuroscience, Michigan State University, 400 Monroe Avenue Northwest, Grand Rapids, MI 49503, USA.
Department of Pharmacology and Toxicology, Michigan State University, 1355 Bogue Street, East Lansing, MI 48824, USA.
Clin Geriatr Med. 2023 Feb;39(1):109-122. doi: 10.1016/j.cger.2022.07.006. Epub 2022 Oct 18.
Aging, familial gene mutations, and genetic, environmental, and modifiable lifestyle risk factors predispose individuals to cognitive impairment or dementia by influencing the efficacy of multiple, often interdependent cellular and molecular homeostatic pathways mediating neuronal, glial, and vascular integrity and, ultimately, cognitive status. This review summarizes data from foundational and recent breakthrough studies to highlight common and differential vascular and nonvascular pathogenic mechanisms underlying the progression of Alzheimer disease, vascular dementia, frontotemporal dementia, and dementia with Lewy bodies.
衰老、家族基因突变以及遗传、环境和可改变的生活方式风险因素，通过影响多种通常相互依存的细胞和分子稳态途径的功效，使个体易患认知障碍或痴呆症，这些途径介导神经元、胶质细胞和血管的完整性，最终影响认知状态。本综述总结了基础研究和近期突破性研究的数据，以突出阿尔茨海默病、血管性痴呆、额颞叶痴呆和路易体痴呆进展过程中常见和不同的血管及非血管致病机制。
