Ermaya Yudith Setiati, Nugraha Eka Surya, Girawan Dolvy, Risan Nelly Amalia, Bestari Muhammad Begawan, Judistiani Raden Tina Dewi, Yuniati Tetty, Prasetyo Dwi
Department of Child Health, Faculty of Medicine, Padjadjaran University, Dr. Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.
Department of Internal Medicine, Faculty of Medicine, Padjadjaran University, Dr. Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.
BMC Pediatr. 2025 Mar 18;25(1):213. doi: 10.1186/s12887-025-05569-w.
Hepatitis B Virus infection is a global health problem. Transplacental maternal antibodies can protect the infant early in life from infection.
This study investigates the correlation between maternal and infant Hepatitis B surface antibodies (anti-HBs) in pairs.
This cross-sectional study measured anti-HBs in paired mother-infant samples. Blood samples were taken from the mother 3 h before delivery and from the newborn immediately after birth by cord blood, and they were then examined for anti-HBs using the Chemiluminescent Microparticle Immunoassay.
Transplacental transfer of maternal anti-HBs was analyzed in 79 mother-infant pairs. Seventeen mothers (21.5%) had positive anti-HBs and all cord blood of newborns from these mothers had anti-HBs detected. Overall, there were 44 (55.7%) newborn blood cords that were positive for anti-HBs. The geometric mean of anti-HBs cord blood titers in newborns with maternal anti-HBs titers < 10, ≥10, ≥ 100, and ≥ 1,000 mIU/mL were 52.42, 193.83, 437.12, and ≥ 1,000 mIU /mL respectively. This study showed a significant correlation in anti-HBs between mother and infant cord blood (r = 0.863; p < 0,001).
Anti-HB antibodies measured in mother and infant cord blood were strongly correlated, demonstrating efficient transplacental antibody transfer to protect infants against Hepatitis B infection. Hepatitis B vaccination is required for mothers to obtain immunogenicity and babies to receive hepatitis B vaccination on time.
乙型肝炎病毒感染是一个全球性的健康问题。经胎盘传递的母体抗体可在婴儿生命早期保护其免受感染。
本研究调查母婴配对的乙型肝炎表面抗体（抗-HBs）之间的相关性。
这项横断面研究检测了母婴配对样本中的抗-HBs。在分娩前3小时采集母亲的血样，出生后立即采集新生儿的脐带血，然后使用化学发光微粒子免疫分析法检测抗-HBs。
对79对母婴进行了母体抗-HBs经胎盘转移的分析。17名母亲（21.5%）抗-HBs呈阳性，这些母亲的所有新生儿脐带血均检测到抗-HBs。总体而言，44份（55.7%）新生儿脐带血抗-HBs呈阳性。母体抗-HBs滴度<10、≥10、≥100和≥1000 mIU/mL的新生儿脐带血抗-HBs滴度几何平均值分别为52.42、193.83、437.12和≥1000 mIU/mL。本研究显示母婴脐带血抗-HBs之间存在显著相关性（r = 0.863；p < 0.001）。
母婴脐带血中检测到的抗-HB抗体高度相关，表明经胎盘抗体有效转移可保护婴儿免受乙型肝炎感染。母亲需要接种乙型肝炎疫苗以获得免疫原性，婴儿需要按时接种乙型肝炎疫苗。
