Yang Liangjun, Fang Zheng, Zhu Jiajie, Li Xiaofang, Yang Bo, Liu Haiyan, Lou Feiyan
Department of Gastroenterology, Tongde Hospital of Zhejiang Province (Zhejiang Academy of Traditional Chinese Medicine), Hangzhou, China.
Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China.
Front Pharmacol. 2025 Mar 4;16:1464498. doi: 10.3389/fphar.2025.1464498. eCollection 2025.
Sijunzi Decoction (SJZD) is a traditional Chinese medicine formula widely used in the treatment of gastrointestinal disorders. Clinical studies have substantiated the efficacy of SJZD in managing conditions such as functional dyspepsia, chronic gastritis, gastric cancer, irritable bowel syndrome, colorectal cancer, and ulcerative colitis. Despite its proven effectiveness, the precise mechanisms by which SJZD operates remain incompletely understood. In this study, we undertake a systematic review of both the clinical applications and the mechanistic underpinnings of SJZD in the context of gastrointestinal disease treatment. Research indicates that SJZD functions through a spectrum of mechanisms including the regulation of intestinal flora, alleviation of inflammation, modulation of immune responses, and facilitation of mucosal repair in the treatment of gastrointestinal ailments. This comprehensive analysis aims to provide a clearer understanding of how SJZD benefits patients with gastrointestinal disorders.
四君子汤是一种广泛用于治疗胃肠道疾病的中药方剂。临床研究已证实四君子汤在治疗功能性消化不良、慢性胃炎、胃癌、肠易激综合征、结直肠癌和溃疡性结肠炎等病症方面的疗效。尽管其有效性已得到证实，但其确切作用机制仍未完全明确。在本研究中，我们对四君子汤在胃肠道疾病治疗中的临床应用和作用机制进行了系统综述。研究表明，四君子汤通过一系列机制发挥作用，包括调节肠道菌群、减轻炎症、调节免疫反应以及促进胃肠道疾病治疗中的黏膜修复。这一综合分析旨在更清楚地了解四君子汤如何使胃肠道疾病患者受益。
