Bromm B
Methods Find Exp Clin Pharmacol. 1985 Mar;7(3):161-9.
This paper describes a series of experimental prerequisites in assessments to measure the efficacy of analgesic drugs in healthy man. Of course, there is no doubt that an analgesic has to prove its validity exactly where it ought to help; i.e. in the patient suffering from pain. But to objectify the mode of action, or to measure dose-response functions, to evaluate the optimal therapeutic dosage, or to compare the relative efficacy of the drug tested with known substances--all these investigations can best be performed in a sample of healthy, informed, intelligent and cooperative volunteers, as homogenous as possible. Various kinds of stimuli used in the experimental pain laboratory will be compared with respect to their usefulness in algesimetry; for example the CO2 laser stimulus and the intracutaneous electrical shock. New examples in the analysis of cerebral potentials evoked by painful stimuli will be presented, such as the principal component analysis, the maximum entropy method, and procedures of cerebral potential mappings. It will be shown that frequency transformation of stimulus-induced changes in the electroencephalogram can result in a powerful tool to verify effects even of the so-called weak analgesics, such as acetyl salicylic acid (Aspirin).
本文描述了在评估用于测量镇痛药对健康人疗效的一系列实验前提条件。当然，毫无疑问，一种镇痛药必须在其理应发挥作用的地方，即在疼痛患者身上证明其有效性。但是，为了使作用方式客观化，或测量剂量反应函数，评估最佳治疗剂量，或比较受试药物与已知药物的相对疗效——所有这些研究最好在尽可能同质的健康、知情、聪明且合作的志愿者样本中进行。将比较实验性疼痛实验室中使用的各种刺激在痛觉测量方面的有用性；例如二氧化碳激光刺激和皮内电击。将给出疼痛刺激诱发脑电位分析中的新例子，如主成分分析、最大熵方法以及脑电位映射程序。将表明，刺激诱发的脑电图变化的频率变换可成为一种有力工具，甚至用于验证所谓弱镇痛药如乙酰水杨酸（阿司匹林）的效果。
