Rohdewald P, Derendorf H, Elger C E, Knoll O
EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb. 1980 Dec;11(4):199-204.
Evoked potentials resulting from stimulation of tooth pulp with rectangular impulses were chosen for the indication of the analgesic activity of mild analgesics. If the stimuli were perceived subjectively as equally painful, the amplitudes of the evoked potentials were intraindividually well reproducible. The results are reproducible within one day as well as on different days. According to the large interindividual variation in the amplitude of the evoked potentials, the percentual reduction of the amplitude was a better measure for the analgesic action than the absolute height of the signal. Interindividually, the latencies have shown clear differences whereas they were reproducible for the individuum. The curves for: 1. The percentual reduction of the evoked potentials 2. The diminuation of the subjective pain response 3. The increase in the sensitivity threshold after the application of the drug were principally similar. The results indicate, that the evoked potentials may represent a more sensitive measure of experimentally induced pain in subjective methods.
选用矩形脉冲刺激牙髓产生的诱发电位来指示轻度镇痛药的镇痛活性。如果主观上认为刺激的疼痛程度相同，诱发电位的幅度在个体内具有良好的可重复性。结果在一天内以及不同日期均可重现。根据诱发电位幅度个体间差异较大，幅度的百分比降低比信号的绝对高度更能衡量镇痛作用。个体间潜伏期存在明显差异，但个体内潜伏期具有可重复性。以下三条曲线基本相似：1. 诱发电位的百分比降低；2. 主观疼痛反应的减弱；3. 用药后感觉阈值的升高。结果表明，在主观方法中，诱发电位可能是实验性诱导疼痛的更敏感指标。
