Zhang Heyu, Li Yanwei, Zhan Luqian, Long Jingfang, Shen Jianing, Chen Jiahui, Qian Jiajing, Pan Zhiming, Wu Xue, Wang Zhen, Wu Wenjun, Huang Guiqian
Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Affiliated With Wenzhou Medical University, Wenzhou, China.
Department of Neurology, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou, China.
Front Aging Neurosci. 2025 Mar 4;17:1525626. doi: 10.3389/fnagi.2025.1525626. eCollection 2025.
Cognitive impairment is an important cause of disability and death among the elderly. One of the most important risk factors is stroke. Post-stroke cognitive impairment (PSCI) not only diminishes the quality of life for patients but also increases the burden on families and society. But PSCI can be mitigated through early intervention. Cerebral small vessel disease (CSVD) is one of the significant causes of stroke and has garnered considerable attention in PSCI. Therefore, this study aims to identify research priorities and trends in PSCI through bibliometric analysis, and further explore the role played by CSVD in PSCI.
In this study, we performed a systematic search in the Science Citation Index Expanded (SCI-E) of the Web of Science Core Collection (WoSCC). VOSviewer, CiteSpace and Origin were mainly used to visualize the research focus and trend in PSCI. In addition, we screened the retrieved literature again, and performed keyword analysis on the studies related to CSVD.
A total of 1,943 publications were retrieved in the field of PSCI in this study, with consistent upward trend in annual publications in recent years. Pendlebury was an important leader in PSCI research. Capital Medical University was in the leading position judging from the number of publications. China had the highest number of publications in this field. The journal Stroke had the strongest international influence in this field. Keywords such as "functional connectivity," "tool," "systematic review," and "meta-analysis" have been revealed to have momentous impact on PSCI in recent years. In the further analysis of PSCI and CSVD, "hypertension," "white matter hyperintensities (WMH)," "cerebral microbleeds (CMBs)," and "cerebral amyloid angiopathy (CAA)" received extensive attention.
The study of PSCI is still in the development stage. This study systematically summarizes the progress and development trend in the field of PSCI, and further explores the relationship between CSVD and PSCI through hypertension and magnetic resonance imaging markers. This study is of great significance for researchers to quickly understand the development of PSCI, but also helps them understand future directions, and provides important insights for the prevention and treatment of PSCI.
认知障碍是老年人致残和死亡的重要原因。最重要的风险因素之一是中风。中风后认知障碍（PSCI）不仅降低了患者的生活质量，还增加了家庭和社会的负担。但PSCI可通过早期干预得到缓解。脑小血管病（CSVD）是中风的重要病因之一，在PSCI领域受到了广泛关注。因此，本研究旨在通过文献计量分析确定PSCI的研究重点和趋势，并进一步探讨CSVD在PSCI中所起的作用。
在本研究中，我们在科学网核心合集（WoSCC）的科学引文索引扩展版（SCI-E）中进行了系统检索。主要使用VOSviewer、CiteSpace和Origin来可视化PSCI的研究重点和趋势。此外，我们再次筛选了检索到的文献，并对与CSVD相关的研究进行了关键词分析。
本研究在PSCI领域共检索到1943篇出版物，近年来年出版物呈持续上升趋势。彭德尔伯里是PSCI研究的重要领军人物。从出版物数量来看，首都医科大学处于领先地位。中国在该领域的出版物数量最多。《中风》杂志在该领域具有最强的国际影响力。近年来，“功能连接”“工具”“系统评价”和“荟萃分析”等关键词对PSCI产生了重大影响。在对PSCI和CSVD的进一步分析中，“高血压”“白质高信号（WMH）”“脑微出血（CMB）”和 “脑淀粉样血管病（CAA）”受到了广泛关注。
PSCI的研究仍处于发展阶段。本研究系统总结了PSCI领域的进展和发展趋势，并通过高血压和磁共振成像标志物进一步探讨了CSVD与PSCI之间的关系。本研究对于研究人员快速了解PSCI的发展具有重要意义，同时也有助于他们了解未来方向，并为PSCI的预防和治疗提供重要见解。
