Huang Liang, Song Dan, Zhong Lei, Liao Xuan, Zhou Xian-Mei, Ge Qian-Min, Ling Qian, Zeng Yan-Mei, Wang Xiao-Yu, Hu Jin-Yu, Chen Cheng, He Liang-Qi, Zhou Qiong, Shao Yi
Fuzhou Aier Ophthalmology Hospital, Fuzhou 344000, Jiangxi Province, China.
Department of Ophthalmology, Peking University International Hospital, Beijing 102206, China.
Int J Ophthalmol. 2025 Mar 18;18(3):469-477. doi: 10.18240/ijo.2025.03.14. eCollection 2025.
To assess the alterations in the resting-state function connections between the two cerebral hemispheres in patients with optic neuritis (ON) and healthy controls (HCs).
A total of 12 ON patients (six males and six females) and 12 HCs (six males and six females) who were highly matched for sex, age, and educational level were recruited. They underwent functional magnetic resonance imaging (fMRI), testing and brain activities were assessed using the degree centrality (DC) method. Correlation analysis between the mean DC values in specific brain areas and behavior performances was analyzed as well. Linear correlations between A anxiety scale (AS) and depression scale (DS) values and DC values in brain regions of patients with ON were also analyzed.
The areas that showed a higher DC value in ON patients were the right angular gyrus and bilateral precuneus, while the left insula and left superior temporal gyrus (LSTG) were regions that presented a lower DC value in ON patients. A receiver operating characteristic (ROC) curve analysis confirmed the accuracy of the area under the curve (AUC) assessment. Linear analysis showed anxiety scale (AS) and depression scale (DS) values in the left insula were both negatively correlated with DC values, while best corrected visual acuity logMAR-R (BCVA logMAR-R) showed a negative correlation with DC in the LSTG.
The study explores altered brain activities of specific regions in patients with ON. The results provide clues for revealing the underlying mechanism of ON development.
评估视神经炎（ON）患者与健康对照者（HCs）两大脑半球静息态功能连接的改变。
招募了12例ON患者（6例男性和6例女性）和12例HCs（6例男性和6例女性），他们在性别、年龄和教育水平上高度匹配。他们接受了功能磁共振成像（fMRI）检查，并使用度中心性（DC）方法评估测试和大脑活动。还分析了特定脑区平均DC值与行为表现之间的相关性分析。此外，还分析了ON患者焦虑量表（AS）和抑郁量表（DS）值与脑区DC值之间的线性相关性。
ON患者中DC值较高的区域是右侧角回和双侧楔前叶，而左侧岛叶和左侧颞上回（LSTG）是ON患者中DC值较低的区域。受试者工作特征（ROC）曲线分析证实了曲线下面积（AUC）评估的准确性。线性分析显示，左侧岛叶的焦虑量表（AS）和抑郁量表（DS）值均与DC值呈负相关，而最佳矫正视力对数最小分辨角（BCVA logMAR-R）与LSTG中的DC呈负相关。
本研究探讨了ON患者特定区域的大脑活动改变。研究结果为揭示ON发生的潜在机制提供了线索。
