[Morphologic findings of the secretory epithelium of the ampulla following ethacrynic acid].

The effect of ethacrynic acid (dose 60 mg./kg. and 100 mg./kg.) on the secretory epithelium of guinea pig ampulla and semicircular epithelium was investigated. With high doses of ethacrynic acid and after long periods (3-4 hours) only, discrete electron microscopic alterations were seen. These consisted mainly in swelling of mitochondria, increase of vesicles, and movement or destruction of melanocytes. Interstitial oedema, well-documented in stria vascularis, was not observed.