Bohne B A, Marks J E, Glasgow G P
Laryngoscope. 1985 Jul;95(7 Pt 1):818-28.
The question of damage to the ear from exposure to ionizing radiation was addressed by exposing groups of chinchillas to fractioned doses of radiation (2 Gy per day) for total doses ranging from 40 to 90 Gy. In order to allow any delayed effects of radiation to become manifest, the animals were sacrificed two years after completion of treatment and their temporal bones were prepared for microscopic examination. The most pronounced effect of treatment was degeneration of sensory and supporting cells and loss of eighth nerve fibers in the organ of Corti. Damage increased with increasing dose of radiation. The degree of damage found in many of these ears was of sufficient magnitude to produce a permanent sensorineural hearing loss.
通过将几组栗鼠暴露于分次剂量的辐射（每天2戈瑞），总剂量范围为40至90戈瑞，来研究电离辐射对耳朵的损伤问题。为了使辐射的任何延迟效应显现出来，在治疗完成两年后对动物实施安乐死，并将它们的颞骨准备好用于显微镜检查。治疗最显著的效果是柯蒂氏器中感觉细胞和支持细胞的退化以及第八神经纤维的丧失。损伤随着辐射剂量的增加而增加。在许多这样的耳朵中发现的损伤程度足以导致永久性感音神经性听力损失。
