Weir David, Wyles Saranya, Behfar Atta, Eaton-Jankov Laura, Secic Michelle, Bell Michaela, Vyas Krishna, Rohrich Rod J
From the Dallas Plastic Surgery Institute, Dallas, TX.
Mayo Clinic, Rochester, MN.
Plast Reconstr Surg Glob Open. 2025 Mar 18;13(3):e6562. doi: 10.1097/GOX.0000000000006562. eCollection 2025 Mar.
The primary aim of this study was to demonstrate the benefits of topical human platelet exosome extract (HPE) (plated) hair serum for improving hair and scalp health in participants with self-perceived thinning hair.
This single-center, placebo-controlled, double-blind study enrolled 39 healthy men and women 18-65 years of age with self-perceived thinning hair. Participants applied either HPE for 9 months or a topical placebo for 6 months with the option to cross over to HPE at 6 months for an additional 3 months. End points included improvements in the global aesthetic appearance of hair, as assessed by a blinded live evaluator; participant-reported outcomes; hair trichoscopy; and independent physician photograph evaluations. Safety data included monitoring for adverse events.
Blinded live evaluator assessments demonstrated statistically significant improvements in the global aesthetic appearance of hair for volume/fullness, density, scalp coverage, and appearance, with all values less than 0.0001 within the HPE group and statistical improvement over the control at months 3 and 6 for volume/fullness, density, and scalp coverage. Participant-reported outcomes for within-group changes for HPE were statistically significant for all hair health parameters, including density, volume fullness, scalp coverage, scalp health, thickness, amount, quality, color, dryness, strength, and overall health of the hair. Hair trichoscopy analyses were significantly improved from baseline within the HPE group. Independent physician photography review demonstrated greater improvements within the HPE group. No adverse effects were observed.
This study demonstrates that topical HPE (plated) hair serum with Renewosome technology significantly improves hair and scalp health and is safe and well tolerated.
本研究的主要目的是证明局部使用人血小板外泌体提取物（HPE）（镀膜）头发精华液对改善自我感觉头发稀疏的参与者的头发和头皮健康的益处。
这项单中心、安慰剂对照、双盲研究招募了39名18至65岁自我感觉头发稀疏的健康男性和女性。参与者使用HPE 9个月或局部安慰剂6个月，并可选择在6个月时交叉使用HPE再持续3个月。终点包括由盲法现场评估者评估的头发整体美学外观的改善；参与者报告的结果；头发毛囊镜检查；以及独立医生的照片评估。安全数据包括监测不良事件。
盲法现场评估者的评估表明，HPE组在头发的整体美学外观方面，在发量/饱满度、密度、头皮覆盖率和外观上有统计学显著改善，所有P值均小于0.0001，且在第3个月和第6个月时，发量/饱满度、密度和头皮覆盖率方面相对于对照组有统计学改善。HPE组内参与者报告的所有头发健康参数的组内变化结果均有统计学意义，包括密度、发量饱满度、头皮覆盖率、头皮健康、厚度、数量、质量、颜色、干燥度、强度和头发整体健康状况。HPE组内头发毛囊镜检查分析较基线有显著改善。独立医生的照片评估显示HPE组有更大改善。未观察到不良反应。
本研究表明，采用Renewosome技术的局部HPE（镀膜）头发精华液能显著改善头发和头皮健康，且安全并耐受性良好。
