Abualiat Zeyad, Alanazi Dalal, Alanazi Mashael, Alwan Maha, Yaqoub Reem, Alhomrani Alhanoof, Alsomali Nouf
Obstetrics and Gynaecology, King Abdulaziz Medical City, Riyadh, SAU.
Obstetrics and Gynaecology, Dr. Sulaiman Al-Habib Medical Group, Riyadh, SAU.
Cureus. 2025 Feb 16;17(2):e79102. doi: 10.7759/cureus.79102. eCollection 2025 Feb.
Among the numerous studies investigating the success rate of intrauterine insemination (IUI), there is a dearth of reliable and applicable data. This retrospective cohort study targeting women in infertile couples aims to provide insight into the local success rate of IUI and its determinants.
To determine the success (pregnancy) rate of IUI and its determinants among infertile couples.
A retrospective cohort study was conducted on women in infertile couples at the King Abdulaziz Medical City (KAMC) in-vitro fertilization (IVF) unit in Riyadh, Saudi Arabia. A total of 238 patients were selected utilizing a non-probability consecutive sampling technique. The success of IUI was determined by the percentage of couples who attained a clinical pregnancy after undergoing the procedure. Data was collected and analyzed using the Statistical Package for Social Sciences (SPSS). Results: The study included 238 women. Their age ranged between 21 and 49 years with an arithmetic mean±SD of 31.6±5.1 years. Regarding causes of infertility, female factors were responsible for 33.2% of cases whereas, in 59.6% of cases, the cause was described as unexplained. The success rate of IUI was 13.4%. Women's gravidity and parity were the only factors significantly associated with the success of IUI as the highest success rate was reported among women with gravidity of 2 (27.6%) and parity of 2 (36%). In contrast, the lowest rates were reported among those of gravidity of 1 (5.9%) and parity of ≥3 (5.9%) with p-values of 0.010 and 0.005, respectively.
When compared to other fertility treatments, the success rate of IUI is relatively low; however, it is comparable to previously reported IUI success rates in other centers in developed countries. It is recommended that a large multi-center study with a bigger sample size be conducted to determine the accuracy on a larger scale. The findings from this study carry valuable implications for guiding the selection of suitable fertility treatments.
在众多调查宫内人工授精（IUI）成功率的研究中，缺乏可靠且适用的数据。这项针对不孕夫妇中女性的回顾性队列研究旨在深入了解当地IUI的成功率及其决定因素。
确定不孕夫妇中IUI的成功（妊娠）率及其决定因素。
在沙特阿拉伯利雅得阿卜杜勒阿齐兹国王医疗城（KAMC）体外受精（IVF）科对不孕夫妇中的女性进行了一项回顾性队列研究。采用非概率连续抽样技术共选取了238例患者。IUI的成功通过接受该程序后达到临床妊娠的夫妇百分比来确定。使用社会科学统计软件包（SPSS）收集和分析数据。结果：该研究纳入了238名女性。她们的年龄在21至49岁之间，算术平均值±标准差为31.6±5.1岁。关于不孕原因，女性因素占33.2%的病例，而59.6%的病例原因不明。IUI的成功率为13.4%。女性的妊娠次数和产次是与IUI成功显著相关的唯一因素，因为妊娠2次（27.6%）和产次2次（36%）的女性成功率最高。相比之下，妊娠1次（5.9%）和产次≥3次（5.9%）的女性成功率最低，p值分别为0.010和0.005。
与其他生育治疗方法相比，IUI的成功率相对较低；然而，它与发达国家其他中心先前报道的IUI成功率相当。建议进行一项样本量更大的大型多中心研究，以在更大范围内确定准确性。本研究结果对指导选择合适的生育治疗方法具有重要意义。
