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沙特阿拉伯王国哈立德·本·苏丹王子生育中心男性因素夫妇辅助生殖技术的结果

The Outcome of Assisted Reproductive Techniques among Couples with Male Factors at Prince Khalid Bin Sultan Fertility Centre, Kingdom of Saudi Arabia.

作者信息

Mukhtar Hytham Bahaeldin, Shaman Amani, Mirghani Hyder Osman, Almasalmah Ayman Adnan

机构信息

Obstetrics and Gynecology, Faculty of Medicine, University of Tabuk, Tabuk, KSA.

Internal Medicine and Endocrinology, Faculty of Medicine, University of Tabuk, Tabuk, KSA.

出版信息

Open Access Maced J Med Sci. 2017 Aug 6;5(5):603-607. doi: 10.3889/oamjms.2017.102. eCollection 2017 Aug 15.

Abstract

BACKGROUND

Thirty-three percent of infertility due to paternal factors, there are an increasing proportion of couples who decide to conceive by assisted reproductive techniques (ART). The outcome prediction is pivotal for decision making.

AIM

We aimed to study the pregnancy outcomes of different ART with male factors infertility.

METHODS

This is retrospective cross-sectional study conducted at Tabuk, Kingdom of Saudi Arabia. One hundred fifteen patients' records reviewed using a structured checklist to collect demographic data, sperm (concentration, motility, and morphology). Female with significant infertility factor were excluded. Chi-square was used for the outcome of various ART.

RESULTS

Out of 115 couples with male factors; treated by Intracytoplasmic Sperm Injection (ICSI), In Vitro Fertilization (IVF) and Intrauterine Insemination (IUI); the mean age was 35.2 ± 6.3 years for men and 29.7 ± 5.1 for females. IVF had the highest success rate overall and had a high pregnancy rate with oligospermia and asthenospermia. ICSI has a good outcome for those with azoospermia, severe oligospermia, and teratozoospermia. IUI must be tried as a first line treatment when semen concentration is more than 10 million sperm/ml. all are not significant (P > 0.05).

CONCLUSION

No significant differences were reported in the pregnancy outcome between various assisted reproductive techniques, smoking, type of infertility and medication.

摘要

背景

因男方因素导致的不孕不育占33%,越来越多的夫妇决定通过辅助生殖技术(ART)受孕。结果预测对于决策至关重要。

目的

我们旨在研究针对男性因素不育的不同辅助生殖技术的妊娠结局。

方法

这是一项在沙特阿拉伯王国塔布克进行的回顾性横断面研究。使用结构化检查表回顾了115例患者的记录,以收集人口统计学数据、精子(浓度、活力和形态)。排除有显著不孕因素的女性。对各种辅助生殖技术的结果使用卡方检验。

结果

在115对有男性因素的夫妇中;接受了卵胞浆内单精子注射(ICSI)、体外受精(IVF)和宫内人工授精(IUI)治疗;男性的平均年龄为35.2±6.3岁,女性为29.7±5.1岁。总体而言,IVF成功率最高,在少精子症和弱精子症患者中妊娠率较高。ICSI对于无精子症、严重少精子症和畸形精子症患者有良好结局。当精液浓度超过1000万精子/毫升时,IUI可作为一线治疗方法尝试。所有差异均无统计学意义(P>0.05)。

结论

在各种辅助生殖技术、吸烟、不孕类型和药物治疗之间,妊娠结局未报告有显著差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/747a/5591588/2c5fd68f433b/OAMJMS-5-603-g001.jpg

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