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A multi-center, prospective, clinical study to evaluate the anti-reflux efficacy of laparoscopic double-flap technique (lD-FLAP Study).一项评估腹腔镜双瓣技术抗反流疗效的多中心、前瞻性临床研究(lD-FLAP研究)。
Ann Gastroenterol Surg. 2024 Feb 22;8(3):374-382. doi: 10.1002/ags3.12783. eCollection 2024 May.
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Short-term outcomes of laparoscopic and robotic distal gastrectomy for gastric cancer: Real-world evidence from a large-scale inpatient database in Japan.腹腔镜和机器人辅助远端胃癌根治术的短期疗效:来自日本大型住院患者数据库的真实世界证据。
J Surg Oncol. 2024 Apr;129(5):922-929. doi: 10.1002/jso.27575. Epub 2024 Jan 4.
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Randomized controlled phase III trial to investigate superiority of robot-assisted gastrectomy over laparoscopic gastrectomy for clinical stage T1-4aN0-3 gastric cancer patients (JCOG1907, MONA LISA study): a study protocol.随机对照 III 期临床试验,旨在研究机器人辅助胃切除术相对于腹腔镜胃切除术治疗 T1-4aN0-3 期胃癌患者的优越性(JCOG1907,MONA LISA 研究):研究方案。
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Robotic Surgery: A Comprehensive Review of the Literature and Current Trends.机器人手术:文献综述与当前趋势
Cureus. 2023 Jul 24;15(7):e42370. doi: 10.7759/cureus.42370. eCollection 2023 Jul.
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Three-year outcomes of robotic gastrectomy versus laparoscopic gastrectomy for the treatment of clinical stage I/II gastric cancer: a multi-institutional retrospective comparative study.机器人胃癌切除术与腹腔镜胃癌切除术治疗临床I/II期胃癌的三年疗效:一项多机构回顾性比较研究。
Surg Endosc. 2023 Apr;37(4):2858-2872. doi: 10.1007/s00464-022-09802-w. Epub 2022 Dec 9.
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Japanese Gastric Cancer Treatment Guidelines 2021 (6th edition).日本胃癌治疗指南 2021(第 6 版)。
Gastric Cancer. 2023 Jan;26(1):1-25. doi: 10.1007/s10120-022-01331-8. Epub 2022 Nov 7.
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Surgical and oncological outcomes of robotic- versus laparoscopic-assisted distal gastrectomy with D2 lymphadenectomy for advanced gastric cancer: a propensity score‑matched analysis of 1164 patients.机器人辅助与腹腔镜辅助进展期胃癌根治术(D2 淋巴结清扫术)的手术及肿瘤学结果:1164 例患者倾向性评分匹配分析。
World J Surg Oncol. 2022 Sep 28;20(1):315. doi: 10.1186/s12957-022-02778-w.
8
Surgical technique of suprapancreatic D2 lymphadenectomy focusing on the posterior hepatic plexus for advanced gastric cancer.针对进展期胃癌,关注肝后丛的胰上 D2 淋巴清扫术的外科技术。
Langenbecks Arch Surg. 2022 Mar;407(2):871-877. doi: 10.1007/s00423-022-02437-4. Epub 2022 Jan 12.
9
Safe implementation of robotic gastrectomy for gastric cancer under the requirements for universal health insurance coverage: a retrospective cohort study using a nationwide registry database in Japan.在全民健康保险覆盖要求下安全实施胃癌机器人胃切除术:一项使用日本全国登记数据库的回顾性队列研究。
Gastric Cancer. 2022 Mar;25(2):438-449. doi: 10.1007/s10120-021-01257-7. Epub 2021 Oct 12.
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Challenges in improving the minimal invasiveness of the surgical treatment for gastric cancer using robotic technology.利用机器人技术提高胃癌手术治疗微创性面临的挑战。
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机器人胃癌切除术的短期和长期结果:一项单中心、单臂前瞻性研究

Short-Term and Long-Term Outcomes of Robotic Gastrectomy for Gastric Cancer: A Single-Center, Single-Arm Prospective Study.

作者信息

Kanaya Nobuhiko, Kuroda Shinji, Kakiutchi Yoshihiko, Kashima Hajime, Kikuchi Satoru, Nishizaki Masahiko, Kagawa Shunsuke, Fujiwara Toshiyoshi

机构信息

Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, JPN.

Department of Surgery, Tsuyama Chuo Hospital, Tsuyama, JPN.

出版信息

Cureus. 2025 Feb 15;17(2):e79063. doi: 10.7759/cureus.79063. eCollection 2025 Feb.

DOI:10.7759/cureus.79063
PMID:40104481
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11913632/
Abstract

BACKGROUND

Robotic gastrectomy (RG) has emerged as a promising approach for gastric cancer (GC) treatment, offering advantages such as enhanced dexterity, improved visualization, and increased precision. However, its widespread adoption remains limited due to technical complexity, high costs, limited applications, and insufficient evidence.

METHODS

We conducted a single-center, prospective study to evaluate the safety and feasibility of RG, including robotic total gastrectomy (RTG), robotic proximal gastrectomy (RPG), and robotic distal gastrectomy (RDG) with D1+ or D2 lymphadenectomy, in clinical stage I/II GC. The primary endpoint was the incidence of intraoperative and postoperative complications, while the secondary endpoints included surgical outcomes and long-term prognosis.

RESULTS

Seven patients were enrolled. No intraoperative complications or conversions to open surgery occurred. The primary endpoint was met, with no major postoperative complications. RTG had a longer operative time and more lymph nodes dissected than RDG and RPG. The median postoperative hospital stay was 10 days. Recurrence was observed in two cases, one of which achieved long-term survival without chemotherapy.

CONCLUSION

Our findings demonstrate the safety and feasibility of RG for early and advanced GC. Further multicenter studies with larger cohorts are needed to establish its oncological benefits and cost-effectiveness, facilitating broader clinical adoption.

摘要

背景

机器人胃癌切除术(RG)已成为一种有前景的胃癌(GC)治疗方法,具有诸如灵活性增强、视野改善和精度提高等优势。然而,由于技术复杂性、高成本、应用受限以及证据不足,其广泛应用仍然有限。

方法

我们开展了一项单中心前瞻性研究,以评估RG(包括机器人全胃切除术(RTG)、机器人近端胃切除术(RPG)以及行D1 + 或D2淋巴结清扫的机器人远端胃切除术(RDG))在临床I/II期GC中的安全性和可行性。主要终点是术中和术后并发症的发生率,次要终点包括手术结果和长期预后。

结果

纳入了7例患者。未发生术中并发症或转为开放手术的情况。达到了主要终点,无重大术后并发症。RTG的手术时间比RDG和RPG长,清扫的淋巴结更多。术后中位住院时间为10天。观察到2例复发,其中1例在未进行化疗的情况下实现了长期生存。

结论

我们的研究结果证明了RG用于早期和进展期GC的安全性和可行性。需要进一步开展更大样本量的多中心研究,以确定其肿瘤学益处和成本效益,促进其更广泛的临床应用。