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自发性斜坡漏及其处理

Spontaneous Clival Leaks and Their Management.

作者信息

Sara Katti Blessi, Upreti Garima, Thomas Habie, Philip Ajay, Sundaresan Rajan, Gandham Edmond Jonathan, Thomas Regi

机构信息

Department of Otorhinolaryngology, Christian Medical College Vellore, Vellore, Tamil Nadu, India.

Department of Otorhinolaryngology, All India Institute of Medical Sciences Rajkot, Rajkot, Gujarat, Rajkot, India.

出版信息

J Neurol Surg B Skull Base. 2024 May 3;86(2):165-172. doi: 10.1055/a-2300-4130. eCollection 2025 Apr.

Abstract

Cerebrospinal fluid (CSF) leaks through the nasal cavity occurrence has a rising trend, of which primary spontaneous leak is 6 to 40% of all the CSF leaks. The most common site of CSF leak is ethmoid roof where the bone is thinner in the entire skull base. Clivus being the hard bone is a rare site for spontaneous leak. We present a case series from a single quaternary care center of this rare occurrence and study its reason and management strategy.  A retrospective surgical audit over a period of 10 years of all patients diagnosed with CSF rhinorrhea was done. A PubMed search was conducted with keywords of CSF leak, CSF rhinorrhea, spontaneous CSF rhinorrhea, clival leak, and clivus to identify the literature and these articles were compiled and their management reviewed.  A total of 100 patients underwent surgical management for spontaneous CSF leak, of which there were 5 patients who had spontaneous CSF rhinorrhea from the clivus. There were four female patients; four patients had high body mass index. The most common site of leak was mid-clivus and surgical technique employed was multilayer dural plasty with a nasoseptal flap and measures were taken to reduce the intracranial pressure intra-operatively and postoperatively.  Spontaneous clival leak is a rare entity with mid and lower clivus being the common site. A combined approach by ENT and neurosurgeons results in best outcome for the patients.

摘要

脑脊液(CSF)经鼻腔漏出的发生率呈上升趋势,其中原发性自发性漏出占所有脑脊液漏的6%至40%。脑脊液漏最常见的部位是筛骨顶部,此处是整个颅底中骨质较薄的部位。斜坡是坚硬的骨质,是自发性漏出的罕见部位。我们展示了来自单一四级医疗中心的这一罕见病例系列,并研究其原因及治疗策略。

对所有诊断为脑脊液鼻漏的患者进行了为期10年的回顾性手术审计。通过在PubMed上搜索关键词“脑脊液漏”“脑脊液鼻漏”“自发性脑脊液鼻漏”“斜坡漏”和“斜坡”来检索文献,并对这些文章进行整理并回顾其治疗方法。

共有100例患者接受了自发性脑脊液漏的手术治疗,其中有5例患者发生了来自斜坡的自发性脑脊液鼻漏。有4例女性患者;4例患者体重指数较高。最常见的漏出部位是斜坡中部,采用的手术技术是多层硬脑膜成形术并使用鼻中隔瓣,术中及术后采取措施降低颅内压。

自发性斜坡漏是一种罕见的情况,斜坡中部和下部是常见部位。耳鼻喉科医生和神经外科医生联合治疗能为患者带来最佳治疗效果。

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Spontaneous Clival Leaks and Their Management.自发性斜坡漏及其处理
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Primary spontaneous cerebrospinal fluid leaks located at the clivus.原发性自发性脑脊液漏位于斜坡。
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本文引用的文献

1
Management of Spontaneous CSF Rhinorrhea: An Institutional Experience.自发性脑脊液鼻漏的管理:一项机构经验。
J Neurol Surg B Skull Base. 2019 Oct;80(5):493-499. doi: 10.1055/s-0038-1676334. Epub 2018 Dec 5.
9
Clival defect causing primary spontaneous rhinorrhea.导致原发性自发性鼻漏的斜坡缺损。
Asian J Neurosurg. 2017 Apr-Jun;12(2):328-330. doi: 10.4103/1793-5482.144202.
10
Spontaneous cerebrospinal fluid fistula in the clivus.斜坡自发性脑脊液漏
Eur Ann Otorhinolaryngol Head Neck Dis. 2017 Dec;134(6):431-434. doi: 10.1016/j.anorl.2016.10.007. Epub 2017 Apr 11.

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