医疗保健专业人员对少肌症干细胞治疗的知识、态度和实践：一项在北京开展的横断面研究

Healthcare Professionals' Knowledge, Attitudes, and Practices Towards Stem Cell Therapy for Sarcopenia: A Cross-Sectional Study in Beijing.

作者信息

Wang Yao, Wang Zhe, Gao Yanan, Zheng Tianru, Liu Tingting

机构信息

Geriatrics Department, Beijing Geriatric Hospital, Beijing, 100095, People's Republic of China.

Rehabilitation and Geriatric Department, Beijing Tongren Hospital Mentougou Campus, Capital Medical University, Beijing, 102300, People's Republic of China.

出版信息

J Multidiscip Healthc. 2025 Mar 14;18:1511-1522. doi: 10.2147/JMDH.S496326. eCollection 2025.

DOI:10.2147/JMDH.S496326

PMID:40104762

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11917437/

Abstract

BACKGROUND

Sarcopenia significantly impacts the aging population, and this study investigates healthcare professionals' knowledge, attitudes, and practices (KAP) towards stem cell therapy for sarcopenia.

METHODS

A cross-sectional study was conducted between January 1, 2024, and March 10, 2024, in medical institutions across Beijing. The study included healthcare professionals aged 18-70 years who completed a self-designed KAP questionnaire (Cronbach's α=0.917). Positive KAP was defined as scoring above 80% of the total score for each dimension.

RESULTS

A total of 451 healthcare professionals participated in the study, with 66.7% female and 41.0% aged 40-49 years. The knowledge, attitude, and practice were 18.00 [10.00, 24.00] (possible range: 12-24), 25.00 [23.00, 30.00] (possible range: 6-30), and 21.00 [16.00, 30.00] (possible range: 7-35), respectively. Of these respondents, 13.7% were healthcare workers in the geriatrics department, who had a positive knowledge score of 22.00 [14.00, 24.00] and a positive attitude score of 29.50 [24.00, 30.00], but their practice scores remain moderate at 27.00 [20.00, 35.00]. Additionally, 140 (31.0%) had treated sarcopenia patients within six months and 277 (61.4%) were employed at public tertiary hospitals with positive knowledge. Multivariate logistic regression indicated that not having treated patients with sarcopenia in the past six months was independently associated with poor knowledge (OR = 0.30, 95% CI: [0.15, 0.62], p = 0.001). Mediating effect analysis showed that knowledge directly affected both attitude (β = 0.475, p < 0.001) and practice (β = 0.127, p = 0.004), and indirectly influenced practice through attitude (β = 0.296, p < 0.001).

CONCLUSION

Healthcare professionals exhibited inadequate knowledge, positive attitudes and inactive practices towards stem cell therapy for sarcopenia. Disease-related healthcare has positive knowledge, but moderate practice. Educational programs are essential to improve knowledge and foster proactive practices among healthcare professionals regarding stem cell therapy for sarcopenia.

摘要

背景

肌肉减少症对老年人群有显著影响，本研究调查了医疗保健专业人员对肌肉减少症干细胞治疗的知识、态度和实践（KAP）。

方法

于2024年1月1日至2024年3月10日在北京的医疗机构进行了一项横断面研究。该研究纳入了年龄在18 - 70岁之间、完成自行设计的KAP问卷（Cronbach's α = 0.917）的医疗保健专业人员。积极的KAP被定义为在每个维度上得分高于总分的80%。

结果

共有451名医疗保健专业人员参与了该研究，其中66.7%为女性，41.0%年龄在40 - 49岁之间。知识、态度和实践得分分别为18.00 [10.00, 24.00]（可能范围：12 - 24）、25.00 [23.00, 30.00]（可能范围：6 - 30）和21.0 [16.00, 30.00]（可能范围：7 - 35）。在这些受访者中，13.7%是老年医学科的医护人员，他们的知识积极得分为22.00 [14.00, 24.00]，态度积极得分为29.50 [24.00, 30.00]，但他们的实践得分保持中等水平，为27.00 [20.00, 35.00]。此外，140名（31.0%）在过去六个月内治疗过肌肉减少症患者，277名（61.4%）受雇于具有积极知识的公立三级医院。多因素逻辑回归表明，在过去六个月内未治疗过肌肉减少症患者与知识水平差独立相关（OR = 0.30，95% CI：[0.15, 0.62]，p = 0.001）。中介效应分析表明，知识直接影响态度（β = 0.475，p < 0.001）和实践（β = 0.127，p = 0.004），并通过态度间接影响实践（β = 0.296，p < 0.001）。