Luo Siyuan, Zhao Chenyu, Wang Rong, Wu Daocheng
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P. R. China.
J Mater Chem B. 2025 Apr 2;13(14):4313-4329. doi: 10.1039/d5tb00026b.
Time-sequenced drug release, or sequential drug release, represents a pivotal strategy in the synergistic treatment of diseases using nanocomposites. Achieving this requires the rational integration of multiple therapeutic agents within a single nanocomposite, coupled with precise time-controlled release mechanisms. These nanocomposites offer many advantages, including enhanced therapeutic synergy, reduced side effects, attenuated adverse interactions, improved stability and optimized drug utilization. Consequently, research in the field of drug delivery and synergistic therapy has become increasingly important. Currently, sequential drug release research is still in the data collection and basic research stages, and its potential has not yet been fully explored. Although prior studies have explored the sequential drug release strategy in various contexts, a comprehensive review of the underlying mechanisms and their applications in nanocomposites remains scarce. This review categorizes different types of sequential drug release strategies and summarizes diverse nanocomposites, focusing on both physical approaches driven by structural variations and chemical methods based on stimulus-responsive mechanisms. Furthermore, we highlight the major applications of sequential drug release strategies in the treatment of various diseases and detail their therapeutic efficacy. Finally, emerging trends and challenges in advancing sequential drug release strategies based on nanocomposites for disease treatment are also discussed.
时间序列药物释放，即顺序药物释放，是使用纳米复合材料协同治疗疾病的关键策略。要实现这一点，需要在单一纳米复合材料中合理整合多种治疗剂，并结合精确的时间控制释放机制。这些纳米复合材料具有许多优点，包括增强治疗协同作用、减少副作用、减轻不良相互作用、提高稳定性和优化药物利用。因此，药物递送和协同治疗领域的研究变得越来越重要。目前，顺序药物释放研究仍处于数据收集和基础研究阶段，其潜力尚未得到充分探索。尽管先前的研究在各种背景下探索了顺序药物释放策略，但对其潜在机制及其在纳米复合材料中的应用的全面综述仍然很少。本综述对不同类型的顺序药物释放策略进行了分类，并总结了各种纳米复合材料，重点关注由结构变化驱动的物理方法和基于刺激响应机制的化学方法。此外，我们强调了顺序药物释放策略在各种疾病治疗中的主要应用，并详细介绍了它们的治疗效果。最后，还讨论了基于纳米复合材料推进顺序药物释放策略用于疾病治疗的新趋势和挑战。
