Yoon Moon Sup, Lee Jae Min, Jo Min Jeong, Kang Su Jeong, Yoo Myeong Kyun, Park So Yeon, Bong Sunghyun, Park Chan-Su, Park Chun-Woong, Kim Jin-Seok, Han Sang-Bae, Lee Hye Jin, Shin Dae Hwan
College of Pharmacy, Chungbuk National University, Cheongju 28160, Republic of Korea.
Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66047, USA.
Gels. 2025 Jul 3;11(7):520. doi: 10.3390/gels11070520.
Dual-drug delivery systems using hydrogel-nanoparticle composites have emerged as a versatile platform for achieving controlled, targeted, and efficient delivery of two distinct therapeutic agents. This approach combines the high loading capacity and tunable release properties of hydrogels with the enhanced stability and targeting ability of nanoparticles, providing synergistic benefits in various biomedical applications. While significant progress has been made, previous research has primarily focused on single-drug systems or simple co-delivery strategies, often lacking precise spatial and temporal control. This gap underscores the need for more sophisticated composite designs that enable programmable, multi-phase release. This review discusses representative fabrication methods, including physical embedding, covalent integration, and layer-by-layer assembly, to offer insights into practical implementation strategies. Also we present recent studies focusing on key applications-including wound healing, cancer therapy, infection prevention, transplant immunosuppression, and tissue regeneration-with an emphasis on composite design and formulation strategies, types of hydrogels and nanoparticles, and mechanisms of dual-drug release and evaluation. Recent advances in nanoparticle engineering and hydrogel formulation have enabled precise control over drug release and improved therapeutic outcomes. Dual-drug delivery systems using hydrogel-nanoparticle composites present a promising approach for overcoming the limitations of conventional monotherapy and achieving synergistic therapeutic effects. Ongoing research continues to optimize the design, efficacy, and safety of these systems, paving the way for their clinical translation.
使用水凝胶-纳米颗粒复合材料的双药递送系统已成为一种多功能平台，可实现两种不同治疗剂的可控、靶向和高效递送。这种方法将水凝胶的高负载能力和可调释特性与纳米颗粒的增强稳定性和靶向能力相结合，在各种生物医学应用中提供协同效益。虽然已取得重大进展，但先前的研究主要集中在单药系统或简单的共递送策略上，往往缺乏精确的空间和时间控制。这一差距凸显了对更复杂的复合设计的需求，这种设计能够实现可编程的多阶段释放。本文综述讨论了代表性的制备方法，包括物理包埋、共价整合和层层组装，以深入了解实际实施策略。我们还介绍了近期专注于关键应用的研究，包括伤口愈合、癌症治疗、感染预防、移植免疫抑制和组织再生，重点关注复合设计和配方策略、水凝胶和纳米颗粒的类型，以及双药释放和评估机制。纳米颗粒工程和水凝胶配方的最新进展使得能够精确控制药物释放并改善治疗效果。使用水凝胶-纳米颗粒复合材料的双药递送系统为克服传统单一疗法的局限性并实现协同治疗效果提供了一种有前景的方法。正在进行的研究继续优化这些系统的设计、疗效和安全性，为它们的临床转化铺平道路。
