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Gastrointestinal histological injury in pigs subjected to triple stent interposition in the thoracoabdominal aorta.

作者信息

Magalhães Angela Claudia Paixão Soares de, Gurgel Gutenberg do Amaral, Barros Svetlana Maria Wanderley de, Valente Miguel Lucas Silva, Aquino Maurício de Amorim, Bessa Sthefanie da Silva, Baquette Rogério Ferraz, Castro Aldemar Araújo, Pitta Guilherme Benjamim Brandão

机构信息

Universidade Federal do Acre - Faculdade de Medicina - Departamento de Cirurgia - Rio Branco (AC) - Brazil.

Universidade Federal do Rio Grande do Sul - Faculdade de Medicina - Departamento de Cirurgia - Porto Alegre (RS) - Brazil.

出版信息

Acta Cir Bras. 2025 Mar 14;40:e402425. doi: 10.1590/acb402425. eCollection 2025.

DOI:10.1590/acb402425
PMID:40105604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11908737/
Abstract

PURPOSE

To evaluate gastrointestinal histological injury in pigs subjected to triple stent interposition versus a control group, hypothesizing no significant injury increase with triple stents.

METHODS

A prospective study with 15 pigs divided into a control group (G0, n = 5) undergoing arteriography only, and a triple stent group (G3, n = 10) undergoing arteriography and three stent implantations in the thoracoabdominal aorta. After an eight-day observation, arteriography, euthanasia, and en bloc gastrointestinal harvesting were performed. Lesions were graded using the Park/Chiu classification, and serum markers were analyzed pre- and post-procedure.

RESULTS

Arteriography confirmed mesenteric artery patency in all animals. Histological analysis showed ischemic lesions in 88.9% of G3, mainly in the colon (89%), compared to 60% in G0, primarily in the colon (60%) and stomach (40%). Most G3 lesions were grade 1, while G0 had higher-grade lesions. Serum markers showed no significant intergroup differences.

CONCLUSION

Triple stent interposition did not significantly increase gastrointestinal injury, indicating its safety for maintaining gastrointestinal perfusion in this model.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/203e/11908737/d9dfe8f82147/1678-2674-acb-40-e402425-gf07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/203e/11908737/9cc04338bf80/1678-2674-acb-40-e402425-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/203e/11908737/0db8b61d2bc0/1678-2674-acb-40-e402425-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/203e/11908737/af619e2e24d3/1678-2674-acb-40-e402425-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/203e/11908737/e8e5e79190ce/1678-2674-acb-40-e402425-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/203e/11908737/7c226278574e/1678-2674-acb-40-e402425-gf05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/203e/11908737/e5f7e6e53790/1678-2674-acb-40-e402425-gf06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/203e/11908737/d9dfe8f82147/1678-2674-acb-40-e402425-gf07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/203e/11908737/9cc04338bf80/1678-2674-acb-40-e402425-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/203e/11908737/0db8b61d2bc0/1678-2674-acb-40-e402425-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/203e/11908737/af619e2e24d3/1678-2674-acb-40-e402425-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/203e/11908737/e8e5e79190ce/1678-2674-acb-40-e402425-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/203e/11908737/7c226278574e/1678-2674-acb-40-e402425-gf05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/203e/11908737/e5f7e6e53790/1678-2674-acb-40-e402425-gf06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/203e/11908737/d9dfe8f82147/1678-2674-acb-40-e402425-gf07.jpg

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