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术中立体定向脑电图（SEEG）和氟代脱氧葡萄糖正电子发射断层扫描（FDG-PET）定制的颞叶切除术（iSP-TR）用于耐药性内侧颞叶癫痫的组织穿刺手术治疗：我们的做法。

The intraoperative SEEG and FDG-PET tailored temporal lobe resection (iSP-TR) for the tissue-spearing surgical treatment of drug-resistant mesial temporal lobe epilepsy: how we do it.

作者信息

Battista Francesca, Carrai Riccardo, Grippo Antonello, Della Puppa Alessandro

机构信息

Department of Neurosurgery, Careggi University Hospital, Florence, Italy.

Neurophysiopathology Unit, Neuro-Muscular-Skeletal Department, Careggi Hospital, University of Florence, Florence, Italy.

出版信息

Acta Neurochir (Wien). 2025 Mar 19;167(1):82. doi: 10.1007/s00701-025-06491-x.

DOI:10.1007/s00701-025-06491-x
PMID:40106065
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11922984/
Abstract

BACKGROUND

For drug-resistant mesial temporal lobe epilepsy (MTLE), surgery is recommended. There is no evidence of a seizure outcome advantage of temporal lobectomy over other strategies despite the high risks of this surgical procedure.

METHODS

We describe a Temporal Resection guided by intraoperative stereo-electroencephalography (iSEEG) and the FluoroDeoxyGlucose PET (FDG PET) (iSP-TR) to treat lesional MTLE. We avoided functional cortical areas using navigated Transcranial Magnetic Stimulation (nTMS).

CONCLUSION

iSP-TR allows for a spare brain parenchyma compared to temporal lobectomy without compromising seizure outcomes.

摘要

背景

对于耐药性内侧颞叶癫痫（MTLE），建议进行手术治疗。尽管该手术风险高，但尚无证据表明颞叶切除术在癫痫发作结局方面优于其他治疗策略。

方法

我们描述了一种在术中立体脑电图（iSEEG）和氟脱氧葡萄糖正电子发射断层扫描（FDG PET）引导下进行颞叶切除术（iSP-TR）来治疗有病灶的MTLE。我们使用导航经颅磁刺激（nTMS）避开功能皮质区域。

结论

与颞叶切除术相比，iSP-TR在不影响癫痫发作结局的情况下可保留脑实质。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd3/11922984/93da7fc58b31/701_2025_6491_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd3/11922984/e1fd0693fef2/701_2025_6491_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd3/11922984/4542a73955e3/701_2025_6491_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd3/11922984/93da7fc58b31/701_2025_6491_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd3/11922984/e1fd0693fef2/701_2025_6491_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd3/11922984/4542a73955e3/701_2025_6491_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bd3/11922984/93da7fc58b31/701_2025_6491_Fig3_HTML.jpg

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本文引用的文献

1
The impact of resective epilepsy surgery on the brain network: evidence from post-surgical imaging.切除性癫痫手术对脑网络的影响：来自术后影像学的证据。
Brain. 2025 Jun 3;148(6):1866-1875. doi: 10.1093/brain/awaf026.
2
Remote effects of temporal lobe epilepsy surgery: Long-term morphological changes after surgical resection.颞叶癫痫手术后的远程影响：手术切除后的长期形态学变化。
Epilepsia Open. 2023 Jun;8(2):559-570. doi: 10.1002/epi4.12733. Epub 2023 Apr 25.
3
Limbic and olfactory cortical circuits in focal seizures.局限性癫痫发作中的边缘和嗅觉皮质回路。
Neurobiol Dis. 2023 Mar;178:106007. doi: 10.1016/j.nbd.2023.106007. Epub 2023 Jan 20.
4
The role of the piriform cortex in temporal lobe epilepsy: A current literature review.梨状皮层在颞叶癫痫中的作用：当前文献综述
Front Neurol. 2022 Nov 21;13:1042887. doi: 10.3389/fneur.2022.1042887. eCollection 2022.
5
Correlation of neuropsychological and metabolic changes after epilepsy surgery in patients with left mesial temporal lobe epilepsy with hippocampal sclerosis.左侧内侧颞叶癫痫伴海马硬化患者癫痫手术后神经心理学与代谢变化的相关性
EJNMMI Res. 2018 Apr 12;8(1):31. doi: 10.1186/s13550-018-0385-5.
6
Anterior temporal lobectomy.前颞叶切除术
Acta Neurochir (Wien). 2016 Jan;158(1):161-6. doi: 10.1007/s00701-015-2640-0. Epub 2015 Nov 23.
7
Functional heterogeneity of the limbic thalamus: From hippocampal to cortical functions.边缘丘脑的功能异质性：从海马功能到皮质功能
Neurosci Biobehav Rev. 2015 Jul;54:120-30. doi: 10.1016/j.neubiorev.2014.11.011. Epub 2014 Nov 21.
8
Long-term postoperative atrophy of contralateral hippocampus and cognitive function in unilateral refractory MTLE with unilateral hippocampal sclerosis.单侧海马硬化所致单侧难治性颞叶内侧癫痫术后对侧海马的长期萎缩与认知功能
Epilepsy Behav. 2014 Jul;36:108-14. doi: 10.1016/j.yebeh.2014.04.028. Epub 2014 Jun 2.
9
Temporal lobe epilepsy surgery and the quest for optimal extent of resection: a review.颞叶癫痫手术与追求最佳切除范围：综述
Epilepsia. 2008 Aug;49(8):1296-307. doi: 10.1111/j.1528-1167.2008.01604.x. Epub 2008 Apr 11.
10
Postoperative alteration of cerebral glucose metabolism in mesial temporal lobe epilepsy.内侧颞叶癫痫术后脑葡萄糖代谢的改变
Brain. 2005 Aug;128(Pt 8):1802-10. doi: 10.1093/brain/awh534. Epub 2005 May 4.