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一种与KNOTTED1类同源框蛋白1相互作用的转录因子SlGATA6维持生长素响应梯度以抑制脱落。

A KNOTTED1-LIKE HOMEOBOX PROTEIN1-interacting transcription factor SlGATA6 maintains the auxin-response gradient to inhibit abscission.

作者信息

Liu Xianfeng, Cheng Lina, Cai Yue, Liu Yang, Yan Xuemei, Liu Jiayun, Li Ruizhen, Ge Siqi, Wang Sai, Liu Xingan, Meng Sida, Qi Mingfang, Jiang Cai-Zhong, Li Tianlai, Xu Tao

机构信息

College of Horticulture, Shenyang Agricultural University, Shenyang, Liaoning 110866, China.

Key Laboratory of Protected Horticulture of Ministry of Education, Shenyang, Liaoning, China.

出版信息

Sci Adv. 2025 Mar 21;11(12):eadt1891. doi: 10.1126/sciadv.adt1891. Epub 2025 Mar 19.

DOI:10.1126/sciadv.adt1891
PMID:40106541
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11922032/
Abstract

The KNOTTED1-LIKE HOMEOBOX PROTEIN1 (SlKD1) is a master abscission regulator in tomato (). Here, we identified an SlKD1-interacting transcription factor GATA transcription factor 6 (SlGATA6), which is required for maintaining the auxin-response gradient and preventing abscission. SlGATA6 up-regulates the expression of and . The AUXIN RESISTANT/LIKE AUXIN RESISTANT (AUX/LAX) proteins SlLAX2-dependent asymmetric auxin distribution causes differential accumulation of Auxin/Indole-3-Acetic Acid 3 (SlIAA3) and its homolog SlIAA32 across different abscission zone cells. It is also required for SUMOylation of AUXIN RESPONSE FACTOR 2a (SlARF2a), a key suppressor of auxin signaling and abscission initiator. Moreover, SlIAA3 and SlIAA32 depress SUMOylated SlARF2a, thus suppressing SlARF2a function. The interaction between SlKD1 and SlGATA6 suppresses SlGATA6 binding to the promoters of and , thereby disrupting the auxin-response gradient and triggering abscission. This regulatory mechanism is conserved under low light-induced abscission in diverse Solanaceae plants. Our findings reveal a critical role of SlKD1 in modulating the auxin-response gradient and abscission initiation.

摘要

类KNOTTED1同源异型盒蛋白1（SlKD1）是番茄中的主要脱落调节因子。在此，我们鉴定出一种与SlKD1相互作用的转录因子GATA转录因子6（SlGATA6），它是维持生长素响应梯度和防止脱落所必需的。SlGATA6上调 和 的表达。生长素抗性/类生长素抗性（AUX/LAX）蛋白SlLAX2依赖性的不对称生长素分布导致生长素/吲哚-3-乙酸3（SlIAA3）及其同源物SlIAA32在不同脱落区细胞中的差异积累。它也是生长素响应因子2a（SlARF2a）SUMO化所必需的，SlARF2a是生长素信号传导的关键抑制因子和脱落启动因子。此外，SlIAA3和SlIAA32抑制SUMO化的SlARF2a，从而抑制SlARF2a的功能。SlKD1与SlGATA6之间的相互作用抑制SlGATA6与 和 启动子的结合，从而破坏生长素响应梯度并触发脱落。这种调节机制在多种茄科植物的弱光诱导脱落过程中是保守的。我们的研究结果揭示了SlKD1在调节生长素响应梯度和脱落起始中的关键作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4416/11922032/2ae4fb301a07/sciadv.adt1891-f8.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4416/11922032/f3c70362debf/sciadv.adt1891-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4416/11922032/2ae4fb301a07/sciadv.adt1891-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4416/11922032/a0782759befc/sciadv.adt1891-f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4416/11922032/5e08be8058f3/sciadv.adt1891-f6.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4416/11922032/2ae4fb301a07/sciadv.adt1891-f8.jpg

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本文引用的文献

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2
Differential CaKAN3-CaHSF8 associations underlie distinct immune and heat responses under high temperature and high humidity conditions.高温高湿条件下，CaKAN3 和 CaHSF8 的差异关联导致不同的免疫和热响应。
Nat Commun. 2023 Jul 25;14(1):4477. doi: 10.1038/s41467-023-40251-8.
3
A SlCLV3-SlWUS module regulates auxin and ethylene homeostasis in low light-induced tomato flower abscission.
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Plant Cell. 2022 Oct 27;34(11):4388-4408. doi: 10.1093/plcell/koac254.
4
The HD-Zip transcription factor SlHB15A regulates abscission by modulating jasmonoyl-isoleucine biosynthesis.HD-Zip 转录因子 SlHB15A 通过调节茉莉酸异亮氨酸生物合成来调控细胞分离。
Plant Physiol. 2022 Aug 1;189(4):2396-2412. doi: 10.1093/plphys/kiac212.
5
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