Wang Jingguang, Zhou Jielong, Xie Zhenze, Zhang Yunhui, He Muye, Wei Tianyu, Wu Shibin, Du Chang
Department of Biomaterials, School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, People's Republic of China.
National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, People's Republic of China.
Biofabrication. 2025 Mar 27;17(2). doi: 10.1088/1758-5090/adc29e.
Tumor recurrence and bone defects are two key challenges in the surgical treatment of osteosarcoma (OS). Therefore, it is highly necessary to develop a multifunctional scaffold that can simultaneously eradicate tumor cells and promote bone regeneration. Herein, a hierarchically porous shape memory scaffold consisting of hydroxyapatite, silica, poly(D,L-lactide-co-trimethylene carbonate) and FeO(HSP-FeO) is constructed by Pickering emulsion and 4D printing technique. The HSP-FeOscaffold demonstrates the advantages of multimodal anti-tumor therapy, including chemotherapy through the Fenton reaction, effective photothermal conversion for photothermal therapy under near-infrared laser irradiation, and magnetothermal therapy provided by an alternating magnetic field. Furthermore, photothermal hyperthermia also serve as triggers for the shape memory effect of the HSP-FeOscaffold, enabling the scaffold to precise adaptation of complex bone defects after minimally invasive surgical implantation. Additionally, the HSP-FeOscaffold with interconnected multiscale pore exhibits good biocompatibility and excellent bone repair capabilities. This study proved that the HSP-FeOscaffold provides positive insights for preventing tumor recurrence and facilitating bone regeneration after OS surgery.
肿瘤复发和骨缺损是骨肉瘤（OS）外科治疗中的两个关键挑战。因此，开发一种能够同时根除肿瘤细胞并促进骨再生的多功能支架非常必要。在此，通过Pickering乳液和4D打印技术构建了一种由羟基磷灰石、二氧化硅、聚（D，L-丙交酯-共-三亚甲基碳酸酯）和FeO组成的分级多孔形状记忆支架（HSP-FeO）。HSP-FeO支架展示了多模态抗肿瘤治疗的优势，包括通过芬顿反应进行化疗、在近红外激光照射下进行光热治疗的有效光热转换以及由交变磁场提供的磁热治疗。此外，光热热疗还可作为HSP-FeO支架形状记忆效应的触发因素，使支架在微创外科植入后能够精确适应复杂的骨缺损。此外，具有相互连接的多尺度孔隙的HSP-FeO支架表现出良好的生物相容性和出色的骨修复能力。这项研究证明，HSP-FeO支架为预防OS手术后的肿瘤复发和促进骨再生提供了积极的见解。
