3-氨基苯甲酰胺不影响辐射诱导的人类细胞中DNA合成的抑制。
3-Aminobenzamide does not affect radiation-induced inhibition of DNA synthesis in human cells.
作者信息
Painter R B
出版信息
Mutat Res. 1985 Jul;143(3):113-5. doi: 10.1016/s0165-7992(85)80019-1.
3-Aminobenzamide (3AB), a potent inhibitor of poly(ADP-ribose) synthesis, does not affect the dose response for ionizing radiation-induced inhibition of DNA synthesis in human fibroblasts. If the radioresistant DNA synthesis observed in fibroblasts from patients with ataxia-telangiectasia (A-T) were due to reduced poly(ADP-ribose) synthesis after irradiation, as has been proposed, the response in normal cells incubated with 3AB would have been similar to that observed in A-T cells. Therefore, altered poly(ADP-ribose) synthesis in A-T cells is not solely responsible for their radioresistant DNA synthesis.
3-氨基苯甲酰胺（3AB）是一种有效的聚（ADP-核糖）合成抑制剂，它不影响电离辐射诱导人成纤维细胞中DNA合成抑制的剂量反应。如果共济失调毛细血管扩张症（A-T）患者成纤维细胞中观察到的辐射抗性DNA合成是由于照射后聚（ADP-核糖）合成减少所致（正如所提出的那样），那么用3AB孵育的正常细胞中的反应将与在A-T细胞中观察到的反应相似。因此，A-T细胞中聚（ADP-核糖）合成的改变并非其辐射抗性DNA合成的唯一原因。
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