Fu Xiao-Man, Li Chen-Lu, Jiang Hong-Ru, Zhang Jia-Yun, Sun Tao, Zhou Feng
The First Clinical Medical College of Shaanxi University of Chinese Medicine, Xianyang, China.
Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Clin Neurol Neurosurg. 2025 May;252:108843. doi: 10.1016/j.clineuro.2025.108843. Epub 2025 Mar 16.
A serious neurosurgical emergency, subarachnoid hemorrhage (SAH) is characterized by vascular and neuropathy, as well as complex pathological mechanisms like vascular lesions, inflammatory responses, and nerve cell damage. The inflammatory response is an essential aspect of SAH's pathophysiology, causing the release of a number of inflammatory mediators and oxidative stress products like TNF-α, MCP-1, MMPs, and so on, which either directly or indirectly contribute to the development of SAH.It has recently been discovered that some antibodies against inflammatory mediators, antioxidant stress, botanicals, and traditional Chinese medicine decrease the inflammatory response of SAH. Additionally, certain biomarkers linked to inflammation may serve as a foundation for clinical diagnosis.Although these mechanisms are still not completely understood, we can explore potential therapeutic targets by studying the role of inflammatory responses and bioactive molecules in the formation of SAH.
蛛网膜下腔出血（SAH）是一种严重的神经外科急症，其特征为血管病变和神经病变，以及诸如血管损伤、炎症反应和神经细胞损伤等复杂的病理机制。炎症反应是SAH病理生理学的一个重要方面，会导致多种炎症介质和氧化应激产物的释放，如肿瘤坏死因子-α（TNF-α）、单核细胞趋化蛋白-1（MCP-1）、基质金属蛋白酶（MMPs）等，这些物质直接或间接促进了SAH的发展。最近发现，一些针对炎症介质、抗氧化应激的抗体、植物药和中药可减轻SAH的炎症反应。此外，某些与炎症相关的生物标志物可作为临床诊断的依据。尽管这些机制仍未完全明确，但我们可以通过研究炎症反应和生物活性分子在SAH形成中的作用来探索潜在的治疗靶点。
