Structural basis of augmenting taurine uptake by the taurine transporter in alleviating cellular senescence.
作者信息
Zhang Heng, Cui Nana, Ma Xiong, Xu H Eric
机构信息
The State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, NHC Key Laboratory of Digestive Diseases, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai, China.
出版信息
Cell Res. 2025 May;35(5):385-388. doi: 10.1038/s41422-025-01090-y. Epub 2025 Mar 20.
Abstract
摘要
相似文献
1
Structural basis of augmenting taurine uptake by the taurine transporter in alleviating cellular senescence.牛磺酸转运体增强牛磺酸摄取以减轻细胞衰老的结构基础。
Cell Res. 2025 May;35(5):385-388. doi: 10.1038/s41422-025-01090-y. Epub 2025 Mar 20.
2
Molecular basis for substrate recognition and transport of mammalian taurine transporters.哺乳动物牛磺酸转运体底物识别与转运的分子基础。
Proc Natl Acad Sci U S A. 2025 Jul 8;122(27):e2425549122. doi: 10.1073/pnas.2425549122. Epub 2025 Jul 2.
3
Dimerization and substrate recognition of human taurine transporter.人牛磺酸转运体的二聚化及底物识别
Nat Commun. 2025 Jul 4;16(1):6163. doi: 10.1038/s41467-025-60967-z.
4
Serum taurine affects lung cancer progression by regulating tumor immune escape mediated by the immune microenvironment.血清牛磺酸通过调节免疫微环境介导的肿瘤免疫逃逸影响肺癌进展。
J Adv Res. 2025 Jul;73:427-442. doi: 10.1016/j.jare.2024.09.005. Epub 2024 Sep 5.
5
Hormetic elevation of taurine restrains inflammaging by deactivating the NLRP3 inflammasome.牛磺酸的兴奋效应通过使NLRP3炎性小体失活来抑制炎症衰老。
bioRxiv. 2025 May 31:2025.05.27.656381. doi: 10.1101/2025.05.27.656381.
6
Taurine enhances growth performance by improving intestinal integrity and antioxidant capacity of weaned piglets.牛磺酸通过改善断奶仔猪的肠道完整性和抗氧化能力来提高生长性能。
J Anim Sci. 2024 Jan 3;102. doi: 10.1093/jas/skae311.
7
Taurine Attenuates Neuronal Ferroptosis by CSF-Derived Exosomes of GABABR Encephalitis Through GABABR/NF2/P-YAP Pathway.牛磺酸通过GABABR脑炎脑脊液衍生的外泌体经GABABR/NF2/P-YAP途径减轻神经元铁死亡。
Mol Neurobiol. 2025 Mar 14. doi: 10.1007/s12035-025-04819-3.
8
A systematic review of preclinical studies on the taurine role during diabetic nephropathy: focused on anti-oxidative, anti-inflammation, and anti-apoptotic effects.糖尿病肾病中牛磺酸作用的临床前研究系统评价：重点关注抗氧化、抗炎和抗细胞凋亡作用。
Toxicol Mech Methods. 2022 Jul;32(6):420-430. doi: 10.1080/15376516.2021.2021579. Epub 2022 Jan 3.
9
Reduced Taurine Transporter Expression in Lymphoblastoid Cell Lines From Alzheimer's Disease Patients Compared With Age-Matched Controls: Therapeutic Implications?与年龄匹配的对照组相比，阿尔茨海默病患者淋巴母细胞系中牛磺酸转运体表达降低：有治疗意义吗？
Drug Dev Res. 2025 Aug;86(5):e70124. doi: 10.1002/ddr.70124.
10
Hypochlorous acid and taurine chloramine co-mediate the innate arm of anti-Vibrio immunity in oyster hemocytes.次氯酸和牛磺酸氯胺共同介导牡蛎血细胞中抗弧菌免疫的先天性免疫反应。
Free Radic Biol Med. 2025 Jun 18;238:78-89. doi: 10.1016/j.freeradbiomed.2025.06.027.
引用本文的文献
1
Molecular basis for substrate recognition and transport of mammalian taurine transporters.哺乳动物牛磺酸转运体底物识别与转运的分子基础。
Proc Natl Acad Sci U S A. 2025 Jul 8;122(27):e2425549122. doi: 10.1073/pnas.2425549122. Epub 2025 Jul 2.
本文引用的文献
1
Transport and inhibition mechanisms of the human noradrenaline transporter.人去甲肾上腺素转运体的转运和抑制机制。
Nature. 2024 Aug;632(8026):930-937. doi: 10.1038/s41586-024-07638-z. Epub 2024 Jul 31.
2
Dimerization and antidepressant recognition at noradrenaline transporter.去甲肾上腺素转运体的二聚化与抗抑郁药识别。
Nature. 2024 Jun;630(8015):247-254. doi: 10.1038/s41586-024-07437-6. Epub 2024 May 15.
3
Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8 T cells.癌症 SLC6A6 介导的牛磺酸摄取反式激活免疫检查点基因，并诱导 CD8 T 细胞衰竭。
Cell. 2024 Apr 25;187(9):2288-2304.e27. doi: 10.1016/j.cell.2024.03.011. Epub 2024 Apr 1.
4
Molecular basis for substrate recognition and transport of human GABA transporter GAT1.人 GABA 转运蛋白 GAT1 的底物识别和转运的分子基础。
Nat Struct Mol Biol. 2023 Jul;30(7):1012-1022. doi: 10.1038/s41594-023-00983-z. Epub 2023 Jul 3.
5
Cryo-EM structure of GABA transporter 1 reveals substrate recognition and transport mechanism.GABA 转运蛋白 1 的冷冻电镜结构揭示了底物识别和转运机制。
Nat Struct Mol Biol. 2023 Jul;30(7):1023-1032. doi: 10.1038/s41594-023-01011-w. Epub 2023 Jul 3.
6
P4HA2 induces hepatic ductular reaction and biliary fibrosis in chronic cholestatic liver diseases.P4HA2 诱导慢性胆汁淤积性肝病中的胆管反应和胆汁性纤维化。
Hepatology. 2023 Jul 1;78(1):10-25. doi: 10.1097/HEP.0000000000000317. Epub 2023 Feb 20.
7
Immune checkpoint therapy-elicited sialylation of IgG antibodies impairs antitumorigenic type I interferon responses in hepatocellular carcinoma.免疫检查点疗法引发的IgG抗体唾液酸化会损害肝细胞癌中抗肿瘤的I型干扰素反应。
Immunity. 2023 Jan 10;56(1):180-192.e11. doi: 10.1016/j.immuni.2022.11.014. Epub 2022 Dec 22.
8
Illumination of serotonin transporter mechanism and role of the allosteric site.血清素转运体机制及变构位点作用的阐明。
Sci Adv. 2021 Dec 3;7(49):eabl3857. doi: 10.1126/sciadv.abl3857. Epub 2021 Dec 1.
9
ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia.ATF3 通过协调丝氨酸和核苷酸代谢来驱动急性髓系白血病中的细胞周期进程。
Mol Cell. 2021 Jul 1;81(13):2752-2764.e6. doi: 10.1016/j.molcel.2021.05.008. Epub 2021 Jun 2.
10
Significance of taurine transporter (TauT) in homeostasis and its layers of regulation (Review).牛磺酸转运蛋白 (TauT) 在体内平衡中的意义及其调节层次 (综述)。
Mol Med Rep. 2020 Sep;22(3):2163-2173. doi: 10.3892/mmr.2020.11321. Epub 2020 Jul 9.
Zotero 插件