Wren John T, Patel Neil, Harting Matthew T, McNamara Patrick J
Division of Neonatology, Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
Department of Neonatology, Royal Hospital for Children, Glasgow, United Kingdom.
J Perinatol. 2025 Apr;45(4):552-561. doi: 10.1038/s41372-025-02265-6. Epub 2025 Mar 19.
Despite a near universal approach focused on physiologic stabilization prior to surgical repair of congenital diaphragmatic hernia (CDH), a condition with significant morbidity and mortality, there remains a lack of consensus, or even guidance, on the appropriate timing for diaphragmatic reconstruction. Hemodynamic-directed care has increasingly been incorporated into the post-natal, peri-operative care of CDH, including assessments of pulmonary hypertension and ventricular dysfunction. Herein, we discuss the integration of targeted neonatal echocardiography and hemodynamic-based assessments to guide precision-directed care and inform selection of the optimal surgical repair window in this complex, heterogeneous patient population.
尽管对于先天性膈疝(CDH)这种具有高发病率和死亡率的疾病,在手术修复前几乎普遍采用专注于生理稳定的方法,但在膈重建的合适时机方面仍缺乏共识甚至指导。以血流动力学为导向的护理已越来越多地纳入CDH的产后围手术期护理,包括对肺动脉高压和心室功能障碍的评估。在此,我们讨论将有针对性的新生儿超声心动图和基于血流动力学的评估相结合,以指导精准护理,并为这一复杂、异质性患者群体选择最佳手术修复时机提供依据。