自闭症谱系障碍儿童大脑复杂性异常：一项睡眠状态功能磁共振成像研究
Abnormalities in brain complexity in children with autism spectrum disorder: a sleeping state functional MRI study.
作者信息
Fu Shishun, Wang Xiang, Chen Ziwei, Huang Zengfa, Feng Yin, Xie Yuanliang, Li Xiang, Yang Chunlan, Xu Shoujun
机构信息
Department of Radiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Radiology, The Third People's Hospital of Chengdu, Chengdu, China.
出版信息
BMC Psychiatry. 2025 Mar 19;25(1):257. doi: 10.1186/s12888-025-06689-4.
BACKGROUND AND OBJECTIVE
The theory of complexity loss in neurodivergent brain is widely acknowledged. However, the findings of autism research do not seem to align well with this theory. We aim to investigate the brain complexity in children with ASD (Autism Spectrum Disorders) compared with the TD (Typical Developed) children in sleeping state.
METHOD
42 ASD children and 42 TD children were imaged using sleep-state functional magnetic resonance imaging (ss-fMRI), and brain complexity was analyzed by employing sample entropy (SampEn) and transfer entropy (TE). For the ASD group, we also investigated the relationship of symptom severity with SampEn and with TE.
RESULTS
In compared with TD group, ASD group showed significant increased SampEn in the right inferior frontal gyrus. However, in the group of TD, 13 pairs of brain regions exhibit higher TE compared to the ASD group. In the ASD group, the TE of 5 pairs of brain regions is higher than in the TD group.
CONCLUSION
This sleeping-state fMRI study provide evidence that ASD children exhibited aberrant brain complexity in compare with the TD children. The complexity of the autistic brain is composed of aberrant randomness in brain activity and anomalous information transmission between brain regions. We believe that brain complexity in ASD is a highly valuable area of research. Differences in the entropy of local brain regions, as well as in the transfer entropy between brain regions, may be related to the brain complexity observed in children with ASD.
背景与目的
神经发育障碍大脑中复杂性丧失的理论已被广泛认可。然而，自闭症研究的结果似乎与该理论不太相符。我们旨在研究与发育正常（TD）儿童相比，自闭症谱系障碍（ASD）儿童在睡眠状态下的大脑复杂性。
方法
对42名ASD儿童和42名TD儿童进行睡眠状态功能磁共振成像（ss-fMRI）扫描，并采用样本熵（SampEn）和转移熵（TE）分析大脑复杂性。对于ASD组，我们还研究了症状严重程度与SampEn以及与TE之间的关系。
结果
与TD组相比，ASD组右侧额下回的SampEn显著增加。然而，在TD组中，有13对脑区的TE高于ASD组。在ASD组中，有5对脑区的TE高于TD组。
结论
这项睡眠状态功能磁共振成像研究提供了证据，表明与TD儿童相比，ASD儿童表现出异常的大脑复杂性。自闭症大脑的复杂性由大脑活动中的异常随机性和脑区之间异常的信息传递组成。我们认为，ASD中的大脑复杂性是一个极具研究价值的领域。局部脑区熵以及脑区之间转移熵的差异可能与ASD儿童中观察到的大脑复杂性有关。
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