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左旋咪唑对肌萎缩侧索硬化症的治疗无效。

Levamisole is ineffective in the treatment of amyotrophic lateral sclerosis.

作者信息

Olarte M R, Shafer S Q

出版信息

Neurology. 1985 Jul;35(7):1063-6. doi: 10.1212/wnl.35.7.1063.

DOI:10.1212/wnl.35.7.1063
PMID:4010949
Abstract

Fifty-nine patients with amyotrophic lateral sclerosis participated in a 12-month, double-blind crossover trial. The patients were given either levamisole 150 mg or placebo in identical tablets once a week orally, and a rating of neurologic signs and symptoms was recorded on monthly visits. The patients were crossed over at 6 months. Levamisole had no effect on the rate of score decline in the 20 patients who completed the trial.

摘要

59例肌萎缩侧索硬化症患者参与了一项为期12个月的双盲交叉试验。患者每周口服一次外观相同的片剂,其中150毫克左旋咪唑或安慰剂,每月就诊时记录神经体征和症状评分。患者在6个月时进行交叉治疗。左旋咪唑对完成试验的20例患者的评分下降率没有影响。

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