Uddman R, Alumets J, Edvinsson L, Håkanson R, Sundler F
Department of Otolaryngology, University Hospital, Malmö, Sweden.
Gastroenterology. 1978 Jul;75(1):5-8.
Nerves displaying vasoactive intestinal polypeptide (VIP) immunoreactivity were demonstrated in the esophagus of rats, cats, and pigs. Furthermore, electron microscopy revealed the presence of nerve terminals displaying the features of peptidergic nerves. VIP nerves were abundant within the smooth muscle layer of the lower esophagus of cat and pig. Immunoreactive nerve fibers and nerve cell bodies were found in the plexuses of the esophageal wall. In pig fetuses VIP immunoreactive nerve cell bodies were observed already at crown-rump length of 4 cm. VIP nerves were also observed in human fetal esophagus. For recording of the motor effects of VIP, segments were taken from cat esophagus close to the esophagogastric junction. VIP induced a dose-dependent relaxation upon contraction by carbamylcholine.
在大鼠、猫和猪的食管中发现了显示血管活性肠肽（VIP）免疫反应性的神经。此外，电子显微镜显示存在具有肽能神经特征的神经末梢。VIP神经在猫和猪食管下段的平滑肌层中丰富。在食管壁的神经丛中发现了免疫反应性神经纤维和神经细胞体。在猪胎儿中，当冠臀长为4厘米时就已观察到VIP免疫反应性神经细胞体。在人类胎儿食管中也观察到了VIP神经。为了记录VIP的运动效应，从靠近食管胃交界处的猫食管中取出节段。VIP在卡巴胆碱引起收缩后诱导剂量依赖性舒张。
