Someko Hidehiro, Takamoto Kazumori, Kataoka Yuki
Department of Healthcare Epidemiology, Graduate School of Medicine, Kyoto University, Kyoto, JPN.
Department of Systematic Reviewers, Scientific Research WorkS Peer Support Group (SRWS-PSG), Osaka, JPN.
Cureus. 2025 Feb 16;17(2):e79114. doi: 10.7759/cureus.79114. eCollection 2025 Feb.
Herpes zoster typically presents with a prodromal phase of pain lasting three to five days before the appearance of characteristic vesicular lesions. We report a case of herpes zoster in an immunocompetent man in his 70s who experienced an unusually prolonged prodromal period of two weeks. The patient initially presented with radicular pain in the right lower extremity, leading to evaluation for lumbar spinal stenosis. After the appearance of vesicular lesions in the L4-S1 dermatomes, he was diagnosed with herpes zoster and treated with valacyclovir and pregabalin. Despite the delayed initiation of therapy, the patient's symptoms resolved completely without recurrence. This case demonstrates that prolonged prodromal periods can occur in immunocompetent individuals and highlights the importance of maintaining clinical suspicion for herpes zoster in cases of persistent radicular pain. Although our patient recovered well despite treatment delay, prompt initiation of antiviral therapy is recommended once herpes zoster is clinically suspected to ensure optimal outcomes.
带状疱疹通常在特征性水疱性皮损出现前有一个持续三到五天的前驱疼痛期。我们报告一例70多岁免疫功能正常男性的带状疱疹病例,其前驱期异常延长至两周。患者最初表现为右下肢神经根性疼痛,因此接受了腰椎管狭窄症的评估。在L4 - S1皮区出现水疱性皮损后,他被诊断为带状疱疹,并接受了伐昔洛韦和普瑞巴林治疗。尽管治疗开始延迟,但患者症状完全缓解且未复发。该病例表明免疫功能正常个体也可能出现前驱期延长的情况,并强调在持续性神经根性疼痛病例中对带状疱疹保持临床怀疑的重要性。虽然我们的患者尽管治疗延迟仍恢复良好,但一旦临床怀疑带状疱疹,建议尽早开始抗病毒治疗以确保最佳疗效。