The regulatory role of miRNAs/mRNAs axis in cancer: a systematic review.

OBJECTIVES

Recently, we and others have demonstrated the involvement of Zinc Finger Antisense 1 () in cancer development. However, the intricate interplay of with miRNAs and mRNAs remains to be fully understood.

MATERIALS AND METHODS

We followed PRISMA guidelines to retrieve and assess the available literature on the topic "/miRNA/mRNA axis" and "Cancer" from databases such as PubMed, Google Scholar, and ScienceDirect. We also used bioinformatic webtools for analyzing the potential miRNA targets of and its role in survival of cancer patients along with their role in various biological functions and pathways.

RESULTS

Our literature search and bioinformatic analysis reveals that serves as a sponge for numerous miRNAs. Among the various targeted miRNAs, miR-150-5p stands out as significantly correlated with across multiple databases (-value = 3.27e-16, value = -0.346). Additionally, our Kaplan-Meier survival analysis indicates a noteworthy association between expression levels and overall poor prognosis and survival rates in ovarian, sarcoma, and pancreatic cancers. We also underscore the involvement of various signaling pathways, including Signal Transducer and Activator of Transcription 3 (STAT3), Spindle and Kinetochore-associated Protein 1 (SKA1), Lysophosphatidic acid receptor 1 (LPAR1), and Wnt β-catenin, in cancer development through the /miRNAs/mRNAs axis. Furthermore, we identify 's pivotal roles in diverse molecular processes, such as RNA binding and ribonucleoprotein formation.

CONCLUSION

In conclusion, this review comprehensively summarizes the latest advancements in understanding the regulatory relationships among , miRNAs, and mRNAs, emphasizing their collective role in cancer development to propose innovative avenues for cancer treatment. We believe that the intricate relationship among the -miRNA-mRNA axis may yield potential therapeutic targets for effective cancer management.