Singh Rahul Kumar, Mandal Surojit, Mohanta Adrija, Yadav Ritu, Kumar Rajiv Ranjan, Khatkar Rinku, Uttam Vivek, Sharma Uttam, Rana Manjit Kaur, Jain Manju, Tuli Hardeep Singh, Jain Aklank
Non-Coding RNA and Cancer Biology Laboratory, Department of Zoology, Central University of Punjab, Ghudda, Bathinda, 151401, India.
Department of Pathology/Lab Medicine, All India Institute of Medical Sciences, Bathinda, 151001, India.
Oncol Res. 2025 Feb 28;33(3):591-604. doi: 10.32604/or.2024.050548. eCollection 2025.
Recently, we and others have demonstrated the involvement of Zinc Finger Antisense 1 () in cancer development. However, the intricate interplay of with miRNAs and mRNAs remains to be fully understood.
We followed PRISMA guidelines to retrieve and assess the available literature on the topic "/miRNA/mRNA axis" and "Cancer" from databases such as PubMed, Google Scholar, and ScienceDirect. We also used bioinformatic webtools for analyzing the potential miRNA targets of and its role in survival of cancer patients along with their role in various biological functions and pathways.
Our literature search and bioinformatic analysis reveals that serves as a sponge for numerous miRNAs. Among the various targeted miRNAs, miR-150-5p stands out as significantly correlated with across multiple databases (-value = 3.27e-16, value = -0.346). Additionally, our Kaplan-Meier survival analysis indicates a noteworthy association between expression levels and overall poor prognosis and survival rates in ovarian, sarcoma, and pancreatic cancers. We also underscore the involvement of various signaling pathways, including Signal Transducer and Activator of Transcription 3 (STAT3), Spindle and Kinetochore-associated Protein 1 (SKA1), Lysophosphatidic acid receptor 1 (LPAR1), and Wnt β-catenin, in cancer development through the /miRNAs/mRNAs axis. Furthermore, we identify 's pivotal roles in diverse molecular processes, such as RNA binding and ribonucleoprotein formation.
In conclusion, this review comprehensively summarizes the latest advancements in understanding the regulatory relationships among , miRNAs, and mRNAs, emphasizing their collective role in cancer development to propose innovative avenues for cancer treatment. We believe that the intricate relationship among the -miRNA-mRNA axis may yield potential therapeutic targets for effective cancer management.
最近，我们和其他研究人员已证明锌指反义1（ ）参与癌症发展。然而， 与微小RNA（miRNA）和信使核糖核酸（mRNA）之间复杂的相互作用仍有待充分了解。
我们遵循系统评价和荟萃分析优先报告项目（PRISMA）指南，从诸如PubMed、谷歌学术和科学Direct等数据库中检索并评估有关“ /微小RNA/信使核糖核酸轴”和“癌症”这一主题的现有文献。我们还使用生物信息学网络工具分析 的潜在微小RNA靶点及其在癌症患者生存中的作用，以及它们在各种生物学功能和途径中的作用。
我们的文献检索和生物信息学分析表明， 充当众多微小RNA的海绵。在各种靶向微小RNA中，miR-150-5p在多个数据库中与 显著相关（P值 = 3.27e-16，皮尔逊相关系数值 = -0.346），因而脱颖而出。此外，我们的卡普兰-迈耶生存分析表明， 表达水平与卵巢癌、肉瘤和胰腺癌的总体预后不良及生存率之间存在显著关联。我们还强调了包括信号转导子和转录激活子3（STAT3）、纺锤体和动粒相关蛋白1（SKA1）、溶血磷脂酸受体1（LPAR1）和Wntβ-连环蛋白在内的各种信号通路通过 /微小RNA/信使核糖核酸轴参与癌症发展。此外，我们确定了 在多种分子过程中的关键作用，如RNA结合和核糖核蛋白形成。
总之，本综述全面总结了在理解 、微小RNA和信使核糖核酸之间调控关系方面的最新进展，强调了它们在癌症发展中的共同作用，为癌症治疗提出了创新途径。我们认为， -微小RNA-信使核糖核酸轴之间的复杂关系可能为有效的癌症管理产生潜在的治疗靶点。
