Tang Weicheng, Wang Kaichen, Feng Yourong, Tsui Kuan-Hao, Singh Keshav K, Stout Michael B, Wang Shixuan, Wu Meng
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
National Clinical Research Center for Obstetrical and Gynecological Diseases, Wuhan 430030, China.
Life Med. 2025 Jan 23;4(1):lnaf004. doi: 10.1093/lifemedi/lnaf004. eCollection 2025 Feb.
The ovary is a crucial gonadal organ that supports female reproductive and endocrine functions. Ovarian aging can result in decreased fertility and dysfunction across multiple organs. Research has demonstrated that cellular senescence in various cell types within the ovary can trigger a decline in ovarian function through distinct stress responses, resulting in ovarian aging. This review explores how cellular senescence may contribute to ovarian aging and reproductive failure. Additionally, we discuss the factors that cause ovarian cellular senescence, including the accumulation of advanced glycation end products, oxidative stress, mitochondrial dysfunction, DNA damage, telomere shortening, and exposure to chemotherapy. Furthermore, we discuss senescence in six distinct cell types, including oocytes, granulosa cells, ovarian theca cells, immune cells, ovarian surface epithelium, and ovarian endothelial cells, inside the ovary and explore their contribution to the accelerated ovarian aging. Lastly, we describe potential senotherapeutics for the treatment of ovarian aging and offer novel strategies for ovarian longevity.
卵巢是一个至关重要的性腺器官，支持女性生殖和内分泌功能。卵巢衰老会导致生育能力下降和多器官功能障碍。研究表明，卵巢内各种细胞类型的细胞衰老可通过不同的应激反应引发卵巢功能下降，从而导致卵巢衰老。本综述探讨了细胞衰老如何导致卵巢衰老和生殖功能衰竭。此外，我们讨论了导致卵巢细胞衰老的因素，包括晚期糖基化终产物的积累、氧化应激、线粒体功能障碍、DNA损伤、端粒缩短以及接触化疗。此外，我们讨论了卵巢内六种不同细胞类型的衰老，包括卵母细胞、颗粒细胞、卵巢膜细胞、免疫细胞、卵巢表面上皮细胞和卵巢内皮细胞，并探讨它们对加速卵巢衰老的作用。最后，我们描述了治疗卵巢衰老的潜在衰老疗法，并为卵巢长寿提供了新的策略。
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