Gerdhem Paul, Wihlborg Axel, Bergström Ingrid B
Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Huddinge, Sweden.
Department of Orthopedics and Hand Surgery, Uppsala University Hospital, Uppsala, Sweden.
Osteoporos Int. 2025 May;36(5):875-882. doi: 10.1007/s00198-025-07412-5. Epub 2025 Mar 20.
Brief rationale: To assess bone dimensions in the radius over 7 years.
Cross-sectional area did not change significantly, but endosteal circumference increased, leading to decreased cortical thickness. Significance of the paper: Bone mineral density loss is associated with a decrease in cortical thickness in the forearm.
To assess site-specific volumetric bone and muscle differences in women with and without forearm fracture in a longitudinal study.
One hundred four postmenopausal women with a forearm fracture and 99 age-matched controls were included and underwent peripheral quantitative computed tomography (pQCT) in the forearm at a mean age of 65 (range 44-88) years and were invited for a reassessment after mean 7 (6-11) years, at which 80 and 79 women took part, respectively. Three cases had movement artifacts on pQCT; 77 cases and 79 controls were finally analysed.
Twenty-two of the cases and 20 of the controls sustained a fracture during the follow-up. From baseline to follow-up, bone mineral content and bone mineral density decreased irrespective of group belonging at baseline, both at the 4% and the 66% level in the forearm. Cross-sectional area did not change significantly at the 4% and the 66% level. At the 66% level, periosteal circumference was unchanged and endosteal circumference increased, leading to decreased cortical thickness. Muscle area decreased, while muscle density was unchanged. A high cross-sectional area and low bone volumetric bone mineral density were predictive of fracture during the follow-up.
Over a mean follow-up of 7 years, postmenopausal women lose bone mineral density, associated with a decrease in cortical thickness in the forearm.
简要原理：评估7年间桡骨的骨尺寸。
横截面积无显著变化，但骨内膜周长增加，导致皮质厚度减小。论文的意义：骨矿物质密度降低与前臂皮质厚度减小有关。
在一项纵向研究中评估有和无前臂骨折的女性特定部位的骨体积和肌肉差异。
纳入104名绝经后前臂骨折女性和99名年龄匹配的对照，平均年龄65岁（范围44 - 88岁）时在前臂进行外周定量计算机断层扫描（pQCT），并在平均7年（6 - 11年）后邀请她们进行重新评估，分别有80名和79名女性参与。3例在pQCT上有运动伪影；最终分析了77例病例和79名对照。
随访期间，22例病例和20名对照发生骨折。从基线到随访，无论基线时所属组别如何，前臂4%和66%水平处的骨矿物质含量和骨矿物质密度均降低。4%和66%水平处的横截面积无显著变化。在66%水平处，骨膜周长不变，骨内膜周长增加，导致皮质厚度减小。肌肉面积减小，而肌肉密度不变。高横截面积和低骨体积骨矿物质密度是随访期间骨折的预测因素。
在平均7年的随访中，绝经后女性骨矿物质密度降低，与前臂皮质厚度减小有关。
