脑血管功能障碍中的性别差异：内皮细胞CD2AP在阿尔茨海默病中的关键作用。
Sexual dimorphism in cerebrovascular dysfunction: The pivotal role of endothelial CD2AP in Alzheimer's disease.
作者信息
Bao Hong, Zheng Shuxin, Shen Yong
机构信息
Department of Neurology and Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China; Neurodegenerative Disorder Research Center, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China; Anhui Province Key Laboratory of Biomedical Aging Research, University of Science and Technology of China, Hefei, China.
Department of Neurology and Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China; Neurodegenerative Disorder Research Center, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China; Anhui Province Key Laboratory of Biomedical Aging Research, University of Science and Technology of China, Hefei, China.
出版信息
Neuron. 2025 Mar 19;113(6):797-800. doi: 10.1016/j.neuron.2025.02.022.
Why there is sex-biased susceptibility to cerebrovascular dysfunction remains enigmatic. Vandal et al. reveal a sex-specific vulnerability to endothelial deficiency in CD2AP, an Alzheimer's disease risk gene, with impaired cerebrovascular reactivity, compromised cerebrovascular function, and cognitive decline, highlighting sex as an important biological variable in Alzheimer's disease.
为何脑血管功能障碍存在性别差异易感性仍是个谜。万德尔等人发现，阿尔茨海默病风险基因CD2AP的内皮缺陷存在性别特异性易损性，伴有脑血管反应性受损、脑血管功能受损和认知能力下降，这凸显了性别是阿尔茨海默病中一个重要的生物学变量。
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