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本文引用的文献

1
Converting TCR-based chimeric antigen receptor STAR into dual-specific targeting receptor for cancer immunotherapy.将基于TCR的嵌合抗原受体STAR转化为用于癌症免疫治疗的双特异性靶向受体。
Mol Ther. 2025 Apr 2;33(4):1552-1565. doi: 10.1016/j.ymthe.2025.02.001. Epub 2025 Feb 5.
2
CAR-Toner: an AI-driven approach for CAR tonic signaling prediction and optimization.嵌合抗原受体(CAR)调节剂:一种用于CAR张力信号预测与优化的人工智能驱动方法。
Cell Res. 2024 May;34(5):386-388. doi: 10.1038/s41422-024-00936-1. Epub 2024 Feb 14.
3
Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness.嵌合抗原受体的电荷密度调节优化了持续信号和 CAR-T 细胞的适应性。
Cell Res. 2023 May;33(5):341-354. doi: 10.1038/s41422-023-00789-0. Epub 2023 Mar 8.
4
Chimeric STAR receptors using TCR machinery mediate robust responses against solid tumors.嵌合 STAR 受体利用 TCR 机制对实体瘤产生强大的反应。
Sci Transl Med. 2021 Mar 24;13(586). doi: 10.1126/scitranslmed.abb5191.
5
A retrospective comparison of CD19 single and CD19/CD22 bispecific targeted chimeric antigen receptor T cell therapy in patients with relapsed/refractory acute lymphoblastic leukemia.复发/难治性急性淋巴细胞白血病患者中CD19单特异性和CD19/CD22双特异性靶向嵌合抗原受体T细胞疗法的回顾性比较
Blood Cancer J. 2020 Oct 19;10(10):105. doi: 10.1038/s41408-020-00371-6.
6
Tumor Antigen Escape from CAR T-cell Therapy.肿瘤抗原逃逸的嵌合抗原受体 T 细胞疗法。
Cancer Discov. 2018 Oct;8(10):1219-1226. doi: 10.1158/2159-8290.CD-18-0442. Epub 2018 Aug 22.
7
Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity.嵌合抗原受体 T 细胞形成非经典且强效的免疫突触,从而驱动快速细胞毒性。
Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E2068-E2076. doi: 10.1073/pnas.1716266115. Epub 2018 Feb 12.
8
Comparison of T Cell Activities Mediated by Human TCRs and CARs That Use the Same Recognition Domains.同种识别域的人 TCRs 和 CARs 介导的 T 细胞活性比较。
J Immunol. 2018 Feb 1;200(3):1088-1100. doi: 10.4049/jimmunol.1700236. Epub 2017 Dec 29.
9
T Cells Expressing CD19/CD20 Bispecific Chimeric Antigen Receptors Prevent Antigen Escape by Malignant B Cells.表达 CD19/CD20 双特异性嵌合抗原受体的 T 细胞可防止恶性 B 细胞发生抗原逃逸。
Cancer Immunol Res. 2016 Jun;4(6):498-508. doi: 10.1158/2326-6066.CIR-15-0231. Epub 2016 Apr 8.

D-STAR: The Gemini Guardians redefining dual-targeting of immune cell therapy.

作者信息

Huang Yuwei, Wang Haopeng

机构信息

School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China; Lingang Laboratory, Shanghai 200031, China.

School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China; Shanghai Clinical Research and Trial Center, Shanghai 201210, China; State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai 201210, China.

出版信息

Mol Ther. 2025 Apr 2;33(4):1312-1314. doi: 10.1016/j.ymthe.2025.03.011. Epub 2025 Mar 19.

DOI:10.1016/j.ymthe.2025.03.011
PMID:40112822
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11997469/
Abstract
摘要