Fanning M M, Kazura J W
Parasite Immunol. 1985 May;7(3):213-22. doi: 10.1111/j.1365-3024.1985.tb00071.x.
The influence of genetic factors on the modulation of hepatosplenomegaly, portal venous pressure and granuloma size in chronic murine schistosomiasis mansoni was studied. Experiments with congenic mice confirmed previous observations that after 8 weeks of infection these disease manifestations are influenced by non-H-2 genes. During chronic infection (20 weeks compared to 8 weeks of infection), hepatosplenomegaly was minimally altered. Portal venous pressure was found to increase in 129/J and BALB/cJ mice, did not change in C57BL/6J and DBA/2J and decreased in CBA/CaJ mice. Simultaneous measurements of granuloma size delineated two groups: decrease of greater than 40%--C57BL/6J, DBA/2J and CBA/CaJ strains and decrease of less than or equal to 20%--129/J, BALB/cJ and C3H/HeJ mice. There was no consistent correlation between the magnitude or direction of alterations in portal pressure and granuloma size among the various strains studied. Furthermore, these alterations were independent of changes in parasite burden (adult worms or hepatic eggs). This amelioration of disease (modulation) was found to be influenced by a small number of non-H-2 genes.
研究了遗传因素对慢性曼氏血吸虫病小鼠肝脾肿大、门静脉压力和肉芽肿大小调节的影响。同基因小鼠实验证实了先前的观察结果，即感染8周后，这些疾病表现受非H-2基因影响。在慢性感染期间（与感染8周相比20周），肝脾肿大变化极小。发现129/J和BALB/cJ小鼠门静脉压力升高，C57BL/6J和DBA/2J小鼠门静脉压力无变化，CBA/CaJ小鼠门静脉压力降低。同时测量肉芽肿大小划分出两组：减小大于40%——C57BL/6J、DBA/2J和CBA/CaJ品系，减小小于或等于20%——129/J、BALB/cJ和C3H/HeJ小鼠。在所研究的不同品系中，门静脉压力变化幅度或方向与肉芽肿大小之间没有一致的相关性。此外，这些变化与寄生虫负荷（成虫或肝内虫卵）的变化无关。发现这种疾病改善（调节）受少数非H-2基因影响。
