McKenzie M E, Johnson J, Long P L
Parasitology. 1985 Jun;90 ( Pt 3):565-72. doi: 10.1017/s0031182000055554.
Evidence exists that lethal activity is associated with extracts from Eimeria tenella-infected caecal tissues. We examined tissues of the small intestine infected with other species of Eimeria for a similar lethal activity. Extracts were prepared from intestinal tissues of chickens infected with either E. acervulina, E. brunetti, E. maxima, E. mitis or E. necatrix. Appropriate control extracts from tissues of non-infected chickens were also prepared. Intravenous injection of the extracts into healthy chickens showed that lethality of infected tissue extracts was higher than control extracts and was independent of the site of infection within the intestine. Comparison of the lethality of caecal extracts from chickens infected with embryo-adapted or parent lines of E. tenella showed that lethality was independent of the recognized pathogenic characteristics of the lines. Also, it was demonstrated that lethal activity is associated with extracts of tissues containing massive numbers of arrested and non-arrested sporozoites and early trophozoites.
有证据表明，致死活性与柔嫩艾美耳球虫感染的盲肠组织提取物有关。我们检查了感染其他艾美耳球虫物种的小肠组织是否具有类似的致死活性。从感染堆型艾美耳球虫、布氏艾美耳球虫、巨型艾美耳球虫、微小艾美耳球虫或毒害艾美耳球虫的鸡的肠道组织中制备提取物。还制备了来自未感染鸡组织的适当对照提取物。将提取物静脉注射到健康鸡体内表明，感染组织提取物的致死率高于对照提取物，且与肠道内感染部位无关。比较感染适应胚胎或亲本系柔嫩艾美耳球虫的鸡的盲肠提取物的致死率表明，致死率与这些品系公认的致病特征无关。此外，还证明致死活性与含有大量静止和非静止子孢子以及早期滋养体的组织提取物有关。
