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First-Line Lenvatinib Plus Pembrolizumab Versus Chemotherapy for Advanced Endometrial Cancer: A Randomized, Open-Label, Phase III Trial.一线乐伐替尼联合帕博利珠单抗对比化疗治疗晚期子宫内膜癌:一项随机、开放标签的III期试验
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Efficacy and safety of dostarlimab in combination with chemotherapy in patients with dMMR/MSI-H primary advanced or recurrent endometrial cancer in a phase 3, randomized, placebo-controlled trial (ENGOT-EN6-NSGO/GOG-3031/RUBY).在一项3期、随机、安慰剂对照试验(ENGOT-EN6-NSGO/GOG-3031/RUBY)中,多斯塔利单抗联合化疗用于错配修复缺陷/微卫星高度不稳定原发性晚期或复发性子宫内膜癌患者的疗效和安全性。
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The fluorescence imaging for laparoscopic and laparotomic endometrial sentinel lymph node biopsy (FILLES) trial: Siriraj gynecologic sentinel node of endometrial cancer (SiGN-En) study.荧光成像在腹腔镜和开腹子宫内膜前哨淋巴结活检中的应用(FILLES)试验:Siriraj 妇科子宫内膜癌前哨淋巴结(SiGN-En)研究。
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Safety, Efficacy, and Biomarker Analyses of Dostarlimab in Patients with Endometrial Cancer: Interim Results of the Phase I GARNET Study.多塔利单抗治疗子宫内膜癌的安全性、有效性和生物标志物分析:GARNET 研究的 I 期结果的中期分析。
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Uterine Neoplasms, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.子宫肿瘤,第1.2023版,美国国立综合癌症网络(NCCN)肿瘤学临床实践指南
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Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with endometrial cancer.泛亚地区适应性欧洲肿瘤内科学会(ESMO)子宫内膜癌诊断、治疗和随访临床实践指南。
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泰国子宫内膜癌管理实践指南:泰国妇科癌症协会共识声明

Practice guideline for management of endometrial cancer in Thailand: a Thai Gynecologic Cancer Society consensus statement.

作者信息

Assavapokee Nicha, Khomphaiboonkij Uraiwan, Tangjitgamol Siriwan, Khunamornpong Surapan, Pongsuvareeyakul Tip, Chanpanitkitchot Saranya, Lertkhachonsuk Arb-Aroon

机构信息

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Department of Gynecologic Oncology, National Cancer Institute, Bangkok, Thailand.

出版信息

J Gynecol Oncol. 2025 Mar;36(2):e96. doi: 10.3802/jgo.2025.36.e96. Epub 2025 Mar 12.

DOI:10.3802/jgo.2025.36.e96
PMID:40114554
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11964982/
Abstract

The Thai Gynecologic Cancer Society (TGCS) continues its efforts to elevate the standard of practice of gynecologic oncologists across all regions of Thailand. A key initiative involves collaborating with the Royal Thai College of Obstetricians and Gynaecologists and the National Cancer Institute, Thailand to regularly update and release clinical practice guidelines (CPGs) for gynecologic cancer. The TGCS released the first CPG for endometrial cancer (EMC) in 2011. Following significant advancements in disease understanding and the major revision of EMC staging by the International Federation of Gynecology and Obstetrics in 2023, national experts collaborated to update the guideline for EMC. The key components of the CPG for EMC covered screening, diagnostic indications and methods, primary treatment including surgical approaches and procedures, pathological processes, adjuvant therapies, and the management of recurrent and advanced diseases through medical or surgical means. The guideline was based on scientific evidence, recommendations from international organizations, and the unique healthcare context of Thailand. The final version reflects a consensus reached through extensive discussions among TGCS members. To share our work with international organizations and healthcare professionals, an English version of the CPG was developed. While it mirrors the content of the Thai version, it differs in length and level of detail. The English version additionally included the level of evidence and a recommendation summary for each section, reflecting common domestic practices, available resources, and coverage under health reimbursement systems.

摘要

泰国妇科癌症协会(TGCS)继续努力提升泰国各地区妇科肿瘤学家的执业水平。一项关键举措是与泰国皇家妇产科学院和泰国国家癌症研究所合作,定期更新并发布妇科癌症的临床实践指南(CPG)。TGCS于2011年发布了首份子宫内膜癌(EMC)临床实践指南。随着对该疾病认识的重大进展以及国际妇产科联合会于2023年对EMC分期进行的重大修订,国内专家共同合作更新了EMC指南。EMC临床实践指南的关键内容涵盖筛查、诊断指征和方法、包括手术入路和操作的初始治疗、病理过程、辅助治疗以及通过药物或手术手段对复发和晚期疾病的管理。该指南基于科学证据、国际组织的建议以及泰国独特的医疗环境制定。最终版本反映了TGCS成员经过广泛讨论达成的共识。为了与国际组织和医疗专业人员分享我们的工作,还编写了CPG的英文版本。虽然它反映了泰文版本的内容,但在长度和详细程度上有所不同。英文版本还为每个部分增加了证据水平和推荐摘要,反映了国内常见做法、可用资源以及健康报销系统的覆盖范围。