Juszczak Kajetan, Dybowski Bartosz, Holecki Michał, Hryniewicz Waleria, Klimek Hanna, Kłoda Karolina, Sieroszewski Piotr, Drewa Tomasz
Department of Urology, Rydygier Memorial Hospital, Krakow, Poland.
Department of Urology and Andrology, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland.
Cent European J Urol. 2024;77(3):520-527. doi: 10.5173/ceju.2024.01.Guid. Epub 2024 Oct 29.
This publication provides a summary of national guidelines developed in response to the regional characteristics of aetiological factors, resistance patterns, and the availability of antibacterial drugs in Poland.
After reviewing the epidemiological evidence, case-control studies, randomised control trials, and current international guidelines and statements, a Polish multidisciplinary group prepared the final recommendations. These recommendations cover diagnosis and management of community-acquired lower urinary tract infections in both genders, pregnant and breastfeeding women, recurrent lower urinary tract infections, and asymptomatic bacteriuria.
The regional choice of antimicrobial agents for first-line therapy of uncomplicated cystitis in women includes fosfomycin trometamol, pivmecillinam, furazidin (furagin), and nitroxoline. For men, co-trimoxazole or fluoroquinolone therapy is recommended. Pivmecillinam and fosfomycin are recommended for the treatment of pregnant and breastfeeding women. For continuous prophylaxis of recurrent urinary tract infections in women, the following antimicrobial agents can be used: fosfomycin trometamol, trimethoprim, furazidin (furagin), and cefaclor. The significance of behavioural management and the use of vaginal hormonal therapy, vaginal probiotics, and immunoprophylaxis is emphasised. Asymptomatic bacteriuria should be treated in pregnant women and in patients prior to surgical intervention in the urinary tract.
New national guidelines based on locally available therapeutic resources should contribute to a more rational choice of therapy in patients with lower urinary tract infection and asymptomatic bacteriuria in Poland.
本出版物总结了根据波兰病因因素、耐药模式及抗菌药物可获得性的区域特征制定的国家指南。
在回顾流行病学证据、病例对照研究、随机对照试验以及当前国际指南和声明后,一个波兰多学科小组制定了最终建议。这些建议涵盖了男女社区获得性下尿路感染、孕妇和哺乳期妇女、复发性下尿路感染以及无症状菌尿的诊断和管理。
女性单纯性膀胱炎一线治疗抗菌药物的区域选择包括磷霉素氨丁三醇、匹美西林、呋喃妥因(呋喃西林)和硝呋太尔。对于男性,推荐复方新诺明或氟喹诺酮类治疗。推荐匹美西林和磷霉素用于治疗孕妇和哺乳期妇女。对于女性复发性尿路感染的持续预防,可使用以下抗菌药物:磷霉素氨丁三醇、甲氧苄啶、呋喃妥因(呋喃西林)和头孢克洛。强调了行为管理以及阴道激素治疗、阴道益生菌和免疫预防的使用。无症状菌尿应在孕妇以及尿路手术干预前的患者中进行治疗。
基于当地可用治疗资源的新国家指南应有助于波兰下尿路感染和无症状菌尿患者更合理地选择治疗方法。