Deji-Oloruntoba Opeyemi, Okpete Uchenna E, Byeon Haewon
Biohealth Convergence Unit, Food and Drug Biotechnology, Inje University, Gimhae 50834, South Korea.
Department of Digital Anti-aging Healthcare (BK21), Inje University, Gimhae 50834, South Korea.
World J Exp Med. 2025 Mar 20;15(1):101289. doi: 10.5493/wjem.v15.i1.101289.
This editorial comments on the study by Pierzynowska investigating the acini-islet-acinar (AIA) reflex, which integrates the exocrine and endocrine functions of the pancreas. The study investigates whether exogenous amylase introduced to the interstitial fluid surrounding pancreatic islets can inhibit insulin release. Historically, high serum amylase levels were associated with pancreatitis, but recent findings suggest that low amylase levels are more linked to metabolic diseases like diabetes and obesity. In their experiment, six pigs were used to examine the effects of amylase infusion on insulin release during an intravenous glucose tolerance test. The pigs received different treatments (amylase, saline, or bovine serum albumin), and blood samples were taken over two hours to measure insulin and glucose levels. The results showed amylase delayed glucose-stimulated insulin release, whereas bovine serum albumin increased insulin levels supporting the existence of the AIA reflex and suggesting amylase as a key metabolic regulator. Enzyme supplementation, particularly with α-amylases, may offer therapeutic benefits in preventing and managing metabolic disorders, including diabetes and obesity. Further research is warranted to explore the full scope of amylase's role in metabolic health and its therapeutic potential.
这篇社论对皮尔齐诺夫斯卡关于腺泡-胰岛-腺泡（AIA）反射的研究进行了评论，该反射整合了胰腺的外分泌和内分泌功能。该研究调查了引入胰岛周围组织液中的外源性淀粉酶是否能抑制胰岛素释放。从历史上看，高血清淀粉酶水平与胰腺炎有关，但最近的研究结果表明，低淀粉酶水平与糖尿病和肥胖等代谢性疾病的联系更为紧密。在他们的实验中，六头猪被用于研究静脉葡萄糖耐量试验期间淀粉酶输注对胰岛素释放的影响。这些猪接受了不同的治疗（淀粉酶、生理盐水或牛血清白蛋白），并在两小时内采集血样以测量胰岛素和葡萄糖水平。结果显示，淀粉酶延迟了葡萄糖刺激的胰岛素释放，而牛血清白蛋白则提高了胰岛素水平，这支持了AIA反射的存在，并表明淀粉酶是一种关键的代谢调节因子。酶补充，特别是α-淀粉酶，可能在预防和管理包括糖尿病和肥胖在内的代谢紊乱方面具有治疗益处。有必要进行进一步的研究，以探索淀粉酶在代谢健康中的作用范围及其治疗潜力。
