DeMesquita S
Pharmacol Biochem Behav. 1985 May;22(5):889-91. doi: 10.1016/0091-3057(85)90542-8.
Rats, fitted with chronic EEG and EMG electrodes and a thoracic pneumograph, were monitored electrophysiologically for three successive days before and after an IP injection of p-chloroamphetamine (PCA) (2 mg/kg). During the 12 hours post PCA treatment, sleep onset was delayed, the percentage of Rapid Eye Movement (REM) sleep was decreased and the breathing rate during both the Non-REM (NREM) and REM sleep states was reduced. By 24 and 48 hours after the PCA injection, the sleep pattern and NREM respiratory rate had returned to control values; however, respiratory rate during REM sleep still tended to be decreased. The results suggest that PCA, at this dose, is capable of inducing insomnia and reducing REM sleep acutely without chronically altering the sleep pattern. The data also suggest that respiratory rate during sleep may decrease following PCA treatment.
给大鼠安装慢性脑电图和肌电图电极以及胸段呼吸描记器，在腹腔注射对氯苯丙胺（PCA）（2毫克/千克）之前和之后连续三天进行电生理监测。在PCA治疗后的12小时内，睡眠开始延迟，快速眼动（REM）睡眠百分比降低，非快速眼动（NREM）和REM睡眠状态下的呼吸频率均降低。在PCA注射后24小时和48小时，睡眠模式和NREM呼吸频率已恢复到对照值；然而，REM睡眠期间的呼吸频率仍趋于降低。结果表明，该剂量的PCA能够急性诱发失眠并减少REM睡眠，而不会长期改变睡眠模式。数据还表明，PCA治疗后睡眠期间的呼吸频率可能会降低。
