Gaggi R, Beltrandi E, Dall'Olio R, Ferri S
Pharmacol Res Commun. 1985 Mar;17(3):209-15. doi: 10.1016/0031-6989(85)90095-5.
Salmon calcitonin (sCT, 2 and 20 U/kg), porcine calcitonin (pCT, 20 and 40 U/kg) and human calcitonin (hCT, 20 and 40 U/kg) were injected subcutaneously to rats trained to eat their food during two hours each day. Food intake and serum Ca++ concentrations were determined at the end of 2h-feeding period. A long lasting anorectic effect was observed for 20 U/kg of sCT with a parallelism between hypocalcaemia and anorexia in the first 8 hours after treatment; on the contrary, rats continued to eat less than controls in the following hours when their serum Ca++ concentrations had risen to normal or even higher levels. As regards pCT and hCT, it was shown that these peptides reduced significantly meal size only for 1-2 hours when serum Ca++ levels were at their lowest levels for these peptides.
将鲑鱼降钙素（sCT，2和20 U/kg）、猪降钙素（pCT，20和40 U/kg）以及人降钙素（hCT，20和40 U/kg）皮下注射给每天训练进食两小时的大鼠。在2小时进食期结束时测定食物摄入量和血清Ca++浓度。观察到20 U/kg的sCT具有持久的厌食作用，在治疗后的前8小时低钙血症与厌食之间存在平行关系；相反，在随后的几个小时里，当大鼠血清Ca++浓度已升至正常甚至更高水平时，它们的进食量仍继续低于对照组。至于pCT和hCT，结果表明，当血清Ca++水平处于这些肽的最低水平时，这些肽仅在1 - 2小时内显著减小进餐量。
