Masala A, Satta G, Alagna S, Anania V, Frassetto G A, Rovasio P P, Semiani A
Pharmacol Res Commun. 1985 Mar;17(3):293-8. doi: 10.1016/0031-6989(85)90104-3.
The effect of clonidine on stress-induced cortisol secretion was studied in 10 patients undergoing general anesthesia for surgery; six other patients served as a control group and none of them was given clonidine. Central and peripheral alpha 2 stimulation by clonidine (average dose:0.45 mg over 60 minutes) was able to completely suppress cortisol release during surgery.
