Bianchi C, Siniscalchi A, Veratti E, Beani L
Pharmacol Res Commun. 1985 Apr;17(4):377-84. doi: 10.1016/0031-6989(85)90017-7.
The effect of morphine on the efflux of (3H) monoamines as well as the endogenous monoamine contents in electrically stimulated brain slices was investigated. Only at a concentration at high as 30 microM did the drug reduce the tritium efflux and counteracted the monoamine depletion caused by prolonged electrical stimulation. This effect was antagonized by Naloxone 10 microM. Besides the good agreement between the two methods used to evaluate drug effects the discrepancy between morphine concentrations active on the neurosecretory process and those effective in the whole animal is stressed. The opioids may act in vivo either by modulating the firing rate of the monaminergic neurons or by affecting other related neuronal pools.
研究了吗啡对电刺激脑片中外流的（3H）单胺以及内源性单胺含量的影响。仅在高达30微摩尔的浓度下，该药物才会减少氚外流，并抵消长时间电刺激引起的单胺耗竭。这种作用被10微摩尔的纳洛酮拮抗。除了用于评估药物作用的两种方法之间的良好一致性外，还强调了对神经分泌过程有活性的吗啡浓度与对整个动物有效的浓度之间的差异。阿片类药物可能在体内通过调节单胺能神经元的放电率或通过影响其他相关神经元池而起作用。
